Optogenetic silencing of long-range projections: basic and translational applications
Heure: 11:00
Lieu: Salle F-1455
Centre de recherche CERVO
Quebec, Quebec G1J 2G3
Une présentation de:
Ofer Yzar
Weizmann Instiute of Science
Long-range communication between brain regions allows synchrony and coordination between distant neural circuits, and is the foundation for complex information processing and behavior. While optogenetic tools have been widely used for the excitation of neuronal cell bodies and axons, optogenetic silencing of long-range transmission has posed significant challenges. We developed a new set of inhibitory bistable rhodopsins that couple to the Gi/o signaling pathway and can be used to suppress synaptic release in vitro and in vivo, in a spatially- and temporally-precise manner. These new tools allow highly light-sensitive silencing and facilitate spectral multiplexing for combined modulation and imaging, opening new and exciting avenues in basic science and potentially in clinical applications.
