Bcl-2 expression in thalamus, brainstem, cerebellum and visual cortex of adult primate.

Publication Type:

Journal Article


Neurosci Res, Volume 42, Issue 4, p.269-77 (2002)


Animals, Apoptosis, Brain Stem, Cell Differentiation, Cerebellum, Fourth Ventricle, Immunohistochemistry, Male, Neuronal Plasticity, Neurons, Proto-Oncogene Proteins c-bcl-2, Saimiri, Thalamus, Third Ventricle, Visual Cortex


<p>Due to the functional importance of Bcl-2, which acts as an anti-apoptotic protein that also affects neural differentiation and adult neurogenesis, we undertook a detailed immunohistochemical study of the distribution of this protein in the brain of squirrel monkeys. The present study describes findings obtained at thalamic, brainstem, cerebellum and visual cortex levels, and the data are compared with our previous results gathered in the same species. At thalamic level, Bcl-2-positive neurons occur in anterior, rostral intralaminar, midline and lateral habenular nuclei. The protein is also expressed in several structures associated with the ventricular system, including the subventricular zone (SVZ), the subcommissural organ, and the periventricular grey at rostral and caudal tips of the fourth ventricle. At brainstem and cerebellar levels, Bcl-2-positive neurons occur in the dorsal raphe nucleus, inferior olivary complex, and in molecular and granular layers of the cerebellum. Finally, neurons of layer IV of the striate cortex display a very strong Bcl-2 immunoreactivity that contrasts with the poor labeling of neurons in adjacent parastriate and peristriate cortices. These finding suggests that Bcl-2 plays a role in the plasticity and structural maintenance of various structures in the primate brain and indicate that the mitotically active SVZ might be more extended along the rostrocaudal axis in primates than in rodents.</p>

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