Listen to a recent interview with Caroline Ménard, who discusses her recent research with Catherine Perrin and Sonia Lupien, which shows that stress can open the blood-brain barrier, allowing pro-inflammatory molecules to enter the brain.
« We knew in an empirical way that chronic stress, in humans and animal, will cause a certain percent of them to develop a depression, says Sonia Lupien. We knew it happened, but we did not know why. Caroline's work provides the first elements of a very, very clear mechanism.
See the original research article in Nature Neuroscience:
Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, Takahashi A, Flanigan ME, Aleyasin H, LeClair KB, Janssen WG, Labonté B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga C, Turecki G, Campbell M, Fayad ZA, Tang CY, Merad M, Russo SJ. Social stress induces neurovascular pathology promoting depression. Nat Neurosci. 2017 Dec;20(12):1752-1760. doi: 10.1038/s41593-017-0010-3.