Cell-specific Investigation of the Neural Circuitry of Memory

Conférence du Centre de recherche CERVO
Date & Time: 
Friday, October 29, 2021 - 13:00
Cliff Kentros

Professor of Neuroscience
Kavli Institute of Systems Neuroscience
Norwegian University of Science and Technology (NTNU)
Trondheim, Norway

Associate Research Professor
Institute of Neuroscience
University of Oregon
Eugene, OR USA


Research Interests

The mammalian brain is arguably the most complex structure known, with trillions of electrically-active cells interconnected in astonishingly intricate ways. Understanding how neural circuits underlie behavior requires having access to their individual components, i.e. neuronal cell types.  Moreover, it is thought that most diseases of the brain have to do with imbalances in neural circuits. However, our current understanding of brain function is more at the level of brain regions rather than the neuronal cell types which are their functional constituents. Distinct cell types throughout brain and body express differing amounts of different genes depending upon differential activation of promoters, the control regions of genes contained in non-coding sequences. We have developed a method whereby we use subcomponents of the genetic machinery that underlies the diversity of neuronal cell types (i.e. enhancers) to create synthetic promoters which are specific to particular neuronal cell types. This allows us to create animal models and viral vectors in which an endless variety of transgenes can be targeted to specific neuronal cell types, allowing us to address neural circuits at the level of granularity at which they actually function. When distributed throughout the scientific community, these neuron-specific tools should lead to fundamental advances in the understanding of both normal and pathological brain function, and potentially provide entirely new avenues of treatment of disorders of the central nervous system.


Participer à la réunion Zoom

ID de réunion : 879 5113 9600
Code secret : 042879

F-1455 et via Zoom
F-1455 et via Zoom

Funding / Support / Partners

logo FRQ-S logo ctrn logo fci logo cihr irsc logo nserc logo MESISentinelle nord