[Cellular basis of transition between sleep and electrographic seizures].

Publication Type:

Journal Article


Med Sci (Paris), Volume 19, Issue 10, p.999-1002 (2003)


Cerebral Cortex, Electroencephalography, Humans, Seizures, Sleep, Unconsciousness


<p>Epileptic seizures mainly develop during slow-wave sleep. Our experiments, using multi-site, extra- and intracellular recordings, show a transformation without discontinuity from sleep patterns to seizures. The cerebral cortex is the minimal substrate of paroxysms with spike-wave complexes at ~3 Hz. Simultaneously, thalamocortical neurons are steadily inhibited and cannot relay signals from the outside world to cortex. This may explain the unconsciousness during certain types of epilepsy.</p>

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