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Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.

Publication Type:

Journal Article

Source:

Neuron, Volume 89, Issue 6, p.1157-72 (2016)

Keywords:

Animals, Chlorides, Homeostasis, Humans, Models, Biological, Neural Inhibition, Nonlinear Dynamics, Synapses

Abstract:

Fast synaptic inhibition relies on tight regulation of intracellular Cl(-). Chloride dysregulation is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition, the consequences of Cl(-) dysregulation are multifaceted and best understood in terms of a dynamical system involving complex interactions between multiple processes operating on many spatiotemporal scales. This dynamical perspective helps explain many unintuitive manifestations of Cl(-) dysregulation. Here we discuss how taking into account dynamical regulation of intracellular Cl(-) is important for understanding how synaptic inhibition fails, how to best detect that failure, why Cl(-) regulation is energetically so expensive, and the overall consequences for therapeutics.

Funding / Support / Partners

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