Claude Gravel

Claude Gravel,
Ph.D.

Director, Gene transfer laboratory


Research Overview

Development of immunological tools for the study and treatment of the brain

Professor Claude Gravel is Director of the Gene Transfer laboratory. He works to combine the tools of gene therapy with those of immunology to develop new therapeutic approaches for the treatment of devastating degenerative diseases such as amyotrophic lateral sclerosis. He has been a pioneer in the use of viral vectors for the treatment of inherited retinal degeneration and motor neuron degeneration in animal models.

Professor Claude Gravel was one of the founding members of the Neurophotonics Center, and is the founder of the Center's Molecular Tools Platform, which is essential to the research of several researchers at the Research Center.


Keywords: 

Gene Therapy, Gene Transfer, Viral Vectors, Neurotrophic Factors, Retina, Motor Neurons, Apoptosis Retinitis, Amyotrophic Lateral, Sclerosis, single-chain-antibodies


Claude Gravel

 
claude.gravel@fmed.ulaval.ca

  
(418) 6635747 ext. 5938

 

2601, chemin de la Canardière
Québec (Québec) G1J 2G3


Office: 
F-3500

Recent Publications

Castonguay A-M, Gravel C, Lévesque M. Treating Parkinson's Disease with Antibodies: Previous Studies and Future Directions. J Parkinsons Dis. 2021;11(1):71-92.
Pozzi S, Thammisetty SSampath, Codron P, Rahimian R, Plourde KValérie, Soucy G, et al.. Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology. J Clin Invest. 2019;129(4):1581-1595.
Gravel M, Béland L-C, Soucy G, Abdelhamid E, Rahimian R, Gravel C, et al.. IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1. J Neurosci. 2016;36(3):1031-48.
Patel P, Kriz J, Gravel M, Soucy G, Bareil C, Gravel C, J-P Julien. Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis. Mol Ther. 2014;22(3):498-510.
Snapyan M, Lemasson M, Brill MS, Blais M, Massouh M, Ninkovic J, et al.. Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. J Neurosci. 2009;29(13):4172-88.
Bédard A, Gravel C, Parent A. Chemical characterization of newly generated neurons in the striatum of adult primates. Exp Brain Res. 2006;170(4):501-12.
Coull JAM, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, et al.. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005;438(7070):1017-21.

Funding / Support / Partners

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