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Disordered RNA chaperone proteins: from functions to disease.

Publication Type:

Journal Article

Source:

Cell Mol Life Sci, Volume 62, Issue 13, p.1409-17 (2005)

Keywords:

Animals, Capsid Proteins, Fragile X Mental Retardation Protein, Fragile X Syndrome, gag Gene Products, Human Immunodeficiency Virus, Gene Products, gag, HIV Infections, HIV-1, Humans, Intellectual Disability, Molecular Chaperones, Nerve Tissue Proteins, Prion Diseases, Prions, Protein Conformation, RNA, RNA-Binding Proteins, Structure-Activity Relationship, Viral Proteins

Abstract:

<p>RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.</p>

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