Electrical conduction block in large nerves: high-frequency current delivery in the nonhuman primate.

Publication Type:

Journal Article

Authors:

Ackermann, D Michael; Christian Ethier; Foldes, Emily L; Oby, Emily R; Tyler, Dustin; Bauman, Matt; Bhadra, Niloy; Miller, Lee; Kilgore, Kevin L

Source:

Muscle Nerve, Volume 43, Issue 6, p.897-9 (2011)

Keywords:

Animals, Electric Conductivity, Electric Stimulation Therapy, Macaca fascicularis, Macaca mulatta, Male, Models, Animal, Nerve Block, Neural Conduction, Peripheral Nerves, Peripheral Nervous System Diseases

Abstract:

<p>Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.</p>