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Endocannabinoid-orexin interactions in the control of metabolism, pain, neuroinflammation and the gut-brain axis

Conférence du Centre de recherche CERVO
Date & Time: 
Friday, December 7, 2018 - 11:00
Vincenzo Di Marzo

Canada Excellence Research Chair 
Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND)
CRIUCPQ and INAF, Université Laval, Quebec City, Canada
Director of the Joint International Research Unit between the CNR and Université Laval for
Chemical and Biochemical Research on the Microbiome and its Impact on Metabolic Health and Nutrition


Research interests and major achievements


  • Discovery of the biosynthetic and metabolic pathways of the endocannabinoids and of some endocannabinoid-like molecules
  • Development of selective inhibitors of endocannabinoid inactivation and biosynthesis
  • Studies of the regulation of endocannabinoid levels in tissues under physiological and pathological conditions and development of profiling techniques for endocannabinoid and endocannabinoid-like molecules
  • First studies on the role of the endocannabinoid system in the regulation of food intake and metabolism
  • Discovery of the anti-tumor actions of endocannabinoids
  • Discovery of the first endovanilloids and their relationships with endocannabinoids
  • Discovery of the role of brain TRPV1 channels in the brain in the control of pain, anxiety and synaptic plasticity
  • Development of dual target drugs with high efficacy and safety in experimental models of chronic pain and anxiety
  • Discovery of the role of the endocannabinoid system in skeletal muscle differentiation
  • Study of the gut microbiome-endocannabinoidome axis in relation to metabolic disorders and related co-morbidities
CERVO Research Centre

Funding / Support / Partners

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