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Femtosecond laser bone ablation with a high repetition rate fiber laser source.

Publication Type:

Journal Article

Source:

Biomed Opt Express, Volume 6, Issue 1, p.32-42 (2015)

Abstract:

<p>Femtosecond laser pulses can be used to perform very precise cutting of material, including biological samples from subcellular organelles to large areas of bone, through plasma-mediated ablation. The use of a kilohertz regenerative amplifier is usually needed to obtain the pulse energy required for ablation. This work investigates a 5 megahertz compact fiber laser for near-video rate imaging and ablation in bone. After optimization of ablation efficiency and reduction in autofluorescence, the system is demonstrated for the in vivo study of bone regeneration. Image-guided creation of a bone defect and longitudinal evaluation of cellular injury response in the defect provides insight into the bone regeneration process.</p>

Funding / Support / Partners

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