Gabriel Bossé, PhD
Zebrafish is an unique model in neuroscience; key neurological pathways are well conserved and we can used genetics and pharmacological tools to investigate brain functions. This model is also suitable for large-scale approaches and drug discovery efforts. We are using a range of techniques from behavioural platforms, imaging, genetic tools (transgenic lines, CRISPR-Cas9) and pharmacological tools. Our main research interest are:
Neurobiology of opioid addiction
We are using a unique opioid self-administration assay to study the molecular pathways involved in drug seeking behaviour.
Impact of neurosteroids on behaviour
Using large scale approaches we are interested in studying the neurological impact of unique neurosteroids.
Long-term consequences of neonatal opioid exposure
We are generating a new zebrafish model to study the behavioural and molecular impact of embryonic opioid exposure
Our group is using zebrafish to study the biological mechanisms involved in controlling behaviour, focusing on opioid addiction.
Using a novel self-administration assay, we are studying the role of neurosteroids in opioid intake and using a combination of pharmacology, genetics, and imaging methods to identify novel biological pathways involves in drug addiction.
We are also developing a new model to study the biological and behavioural consequences of neonatal opioid exposure in zebrafish.
Our behaviour-based platform is also used to perform small molecule screening to identify novel neuroactive molecules. The compounds uncovered and their cellular targets have the potential to uncover novel pathways and therapeutic approaches, as I have already shown with finasteride.
Manuscrits revus et publiés
Carmack SA, Vendruscolo JM, McGinn A, Miranda-Barrientos J, Hinrich AJ, Bosse GD, Repunte-Canonigo V, Jodelka FM, Rigo F, Ling K, Messing R, Peterson RT, Edwards S, Sanna PP, Morales M, Hasting ML, Koob GF, Vendruscolo LF (2022), Corticosteroid-Dependent Sensitization to Stress Drives Opioid Addiction, Molecular Psychiatry 27, pages2492–2501, IF 12.384
Bosse GD, Cadeddu R, Floris G, Farero DR, Vigato E, Janet Lee, Zhang T, Gaikward N, Keefe K, Philips PEM, Bortolato M, Peterson RT (2021), The 5α-reductase inhibitor finasteride reduces opioid self-administration, Journal of Clinical Investigation, May 17;131(10):e143990, doi: 10.1172/JCI143990. IF 19.456
Bosse GD, Urcino C, Kozel S, Cabang A, Florez-Salcedo P, Chase K, Watkins M, Savafi-Hemami H, Raguraman S, Olivera B, Peterson RT, Gajewiak J (2021),Discovery of a potent Conorfamide from Conus episcopatus using a novel zebrafish larvae assay, Journal of Natural Products. Mar 25 doi: 10.1021/acs.jnatprod.0c01297, Cover art IF 4.050
Weeks O, Bosse GD, Oderberg IM, Akle S, Houvras Y, Wrigthon PJ, LaBella K, Iversen I, Tavakoli S, Adatto I, Shwartz A, Loosterman D, Tsomides A, Charness M, Peterson RT, Steinhauser M, Pouneh F, Goessling W (2020), Fetal Alcohol Spectrum Disorder Predisposes to Metabolic Abnormalities in Adulthood, Journal of Clinical Investigation, May 1;130(5):2252-2269 IF 19.456
Bosse GD and Peterson RT (2017), Development of an opioid self-administration assay to study drug seeking in zebrafish, Behavioral Brain Research, 335, 158-166, Sep 29 IF 3.332
Wang CL, Gupta P, Fressigne L, Bosse GD, Wang XI, Simard MJ, Hanser D (2017), TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C.elegans and human cells, Nucleic Acid Research, Feb 17;45(3):1488-1500 IF 19.160
Meziane O, Piquet S, Bosse GD, Gagne D, Paquet E, Robert C, Tones MA, Simard MJ (2015), The human decapping scavenger enzyme DcpS modulates microRNA turnover, Scientific Report, Nov 20;5:16688 IF 4.886
Bosse GD, Rüegger S, Ow MC, Vasquez-Rifo A, Rondeau EL, Ambros VR, Groshans H, Simard MJ (2013), The Decapping Scavenger Enzyme DCS-1 Controls MicroRNA Levels in Caenorhabditis elegans, Molecular Cell, 2013 Apr 25;50(2):281-7 IF 17.97
Vasquez-Rifo A, Bosse GD, Rondeau EL, Jannot G, Dallaire A, Simard MJ (2013), A new Role for the GARP Complex in MicroRNA-Mediated Gene Regulation, PLoS Genetics, Nov;9(11)e1003961 IF 5.917
2601 Chemin de la Canardière Québec (Québec) G1J 2G3 Canada