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Galectin-3: mediator of microglia responses in injured brain.

Publication Type:

Journal Article

Source:

Drug Discov Today, Volume 23, Issue 2, p.375-381 (2018)

Abstract:

<p>Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.</p>

Funding / Support / Partners

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