Isabelle St-Amour,
PhD

Adjunct Professor, Faculty of Pharmacy, Université Laval

Research Overview

The sequence of events that leads to a neurodevelopmental disorder and brain diseases is still poorly understood, which impairs our ability to treat. Our laboratory is interested in investigating the link between genetic susceptibilities and immune activation in neurodegenerative diseases and neurodevelopmental disorders . We are also studying the role of specific microRNAs in neural network maturation.

Key Publications

Petry, S., Keraudren, R., Nateghi, B., Loiselle, A., Pircs, K., Jakobsson, J., Sephton, C., Langlois, M., *St-Amour, I., & *Hébert, S. S. (2022). Widespread alterations in microRNA biogenesis in human Huntington’s disease putamen. Acta Neuropathol Commun, 10(1), 106.

Petry, S., Nateghi, B., Keraudren, R., Sergeant, N., Planel, E., Hébert, S. S., & St-Amour, I. (2022). Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington’s Disease Brain. Neuroscience, S0306-4522(22)00367.

Keywords:

Huntington's disease, Alzheimer's disease, Autism spectrum disorder, Rett syndrome, microRNA, adaptive immunity, prenatal immune activation

isabelle.st-amour@cervo.ulaval.ca

2601 Chemin de la Canardière Québec (Québec) G1J 2G3 Canada

Recent Publications

Petry S, Keraudren R, Nateghi B, Loiselle A, Pircs K, Jakobsson J, et al.. Widespread alterations in microRNA biogenesis in human Huntington's disease putamen. Acta Neuropathol Commun. 2022;10(1):106.

Petry S, Nateghi B, Keraudren R, Sergeant N, Planel E, Hébert SS, et al.. Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington's Disease Brain. Neuroscience. 2022;.

Pircs K, Drouin-Ouellet J, Horváth V, Gil J, Rezeli M, Garza R, et al.. Distinct subcellular autophagy impairments in induced neurons from Huntington's disease patients. Brain. 2021;.

Boscher E, Hernandez-Rapp J, Petry S, Keraudren R, Rainone S, Loiselle A, et al.. Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212. Front Neurol. 2020;11:578720.

Gagné A-M, Moreau I, St-Amour I, Marquet P, Maziade M. Retinal function anomalies in young offspring at genetic risk of schizophrenia and mood disorder: The meaning for the illness pathophysiology. Schizophr Res. 2020;219:19-24.

St-Amour I, Bosoi CR, Paré I, Doss PMercy Igna, Rangachari M, Hébert SS, et al.. Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2019;16(1):3.

Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Rowley JW, Cloutier N, et al.. Platelet abnormalities in Huntington's disease. J Neurol Neurosurg Psychiatry. 2019;90(3):272-283.

Lamontagne-Proulx J, St-Amour I, Labib R, Pilon J, Denis HL, Cloutier N, et al.. Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease. Neurobiol Dis. 2019;124:163-175.

Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Weiss A, Chouinard S, et al.. Platelet-derived extracellular vesicles in Huntington's disease. J Neurol. 2018;265(11):2704-2712.

Pircs K, Petri R, Madsen S, Brattås PLudvik, Vuono R, Ottosson DR, et al.. Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation. Cell Rep. 2018;24(6):1397-1406.

Funding / Support / Partners

© Gouvernement du Québec