Jasna Kriz publishes in Cell Reports

In an article published in Cell Reports, Dr Jasna Kriz's team reports on the discovery of a new mechanism controlling the innate immune response of microglia relying on messenger RNA (mRNA) translation on ribosomes.  By using a model system for in vivo analysis of ribosomes, her team found a dichotomy in the mRNA networks undergoing translation and the proteins being synthesized in microglia following the induction of the innate immune response.  Surprisingly, the mRNAs that are highly regulated by inflammation are blocked in translation on ribosomes by interactions of their 3'UTR with a protein called SRSF3. 

This discovery open new therapeutic avenues to modulate the innate immune response of brain microglia. 

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