Professeur Agrégé / Associate Professor
Co-director Cancer Research Centre - Université Laval
Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Faculté de médecine
Axe Oncologie - Centre de Recherche CHU de Québec-Université Laval
Well-regulated gene expression networks are responsible for establishing and maintaining cellular states during development. Of the early cell states present in development, pluripotency is the cellular state that has the potential to derive all cell lineages of the embryo. Mutations in genes associated with pluripotency often lead to abnormal development and embryo lethality, but much of the focus relating to these genes has been on protein-coding genes. However, the last decade has seen the rise of long non-coding RNAs (lncRNAs) as novel players in the control of pluripotency, development, and several diseases including cancer and neurological disorders. As such, our major goal is to understand the molecular mechanisms and functional interactions of lncRNAs in modulating cellular states. In this talk, I will discuss how these lncRNA interactions influence mRNA splicing, gene expression, and ultimately cell fate, but more specifically in the context of pluripotency.
Participer à la réunion Zoom
ID de réunion : 833 9897 3912
Code secret : 725857