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Luca Pellegrini,

Molecular mechanisms of mitochondrial dynamics
The regulation of primary mitochondrial activities like ATP synthesis, calcium signaling and apoptosis impinges on the activity of proteins controlling the shape and structure of the mitochondrial network. Consequently, dysfunctions in mitochondria biogenesis and homeostasis are central to the development of a plethora of degenerative diseases and metabolic syndromes.

To understand the etiology of these disorders it is imperative to discover, therefore, how mitochondria morphology remodeling is regulated and which signaling pathways link physiological transitions to structural changes of the mitochondrial architecture. To this goal, the machinery coordinating mitochondria membrane fusion and fission must be dissected, and its mechanism of regulation understood.

In the PelleLAB we are working toward this goal by studying the mechanism of regulation of the rhomboid protease PARL and of the dynamin-related GTPase OPA1, two central regulators of mitochondria morphology and structure.


Molecular mechanisms of mitochondrial dynamics



2601 Chemin de la Canardiere
Québec (Québec) G1J 2G3




The coming of age of the mitochondria-ER contact: a matter of thickness., Giacomello, M, and Pellegrini Luca , Cell Death Differ, 2016 Sep 01, Volume 23, Issue 9, p.1417-27, (2016)
The dynamin GTPase OPA1: more than mitochondria?, Belenguer, Pascale, and Pellegrini Luca , Biochim Biophys Acta, 2013 Jan, Volume 1833, Issue 1, p.176-83, (2013)
The PARL family of mitochondrial rhomboid proteases., R Hill, Blake, and Pellegrini Luca , Semin Cell Dev Biol, 2010 Aug, Volume 21, Issue 6, p.582-92, (2010)
Calcium regulation of mitochondria motility and morphology., Jeyaraju, Danny V., Cisbani Giulia, and Pellegrini Luca , Biochim Biophys Acta, 2009 Nov, Volume 1787, Issue 11, p.1363-73, (2009)

Funding / Support / Partners

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