Our research bears on orofacial rhythms, more particularly on the generation of whisking in rodents.
In prior studies we discovered a pool of glycinergic neurons in the medulla whose activity is essential for whisking generation.
Our current studies aim at determining more precisely the phenotype of these glycinergic cells, and at identifying the neuronal circuits that control their activity.
Our experimental approaches include: unit recordings in head-restrained animals, circuit tracing by means of viruses, high-speed video monitoring of behavior, and other standard methods like immunohistochemistry, in situ hybridization, etc.
Moore JD, Deschênes M, Furuta T, Huber D, Smear MC, Demers M, Kleinfeld D (2013) Hierarchy of orofacial rhythms revealed through whisking and breathing. Nature 497: 205–210.
Kleinfeld D, Deschênes M, Wang F, Moore JD (2014) More than a rhythm of life: breathing as a binder of orofacial sensation. Nat. Neurosci 17: 647–651.
Moore JD, Mercer Lindsay N, Deschênes M, Kleinfeld D (2015) Vibrissa self-motion and touch are reliably encoded along the same somatosensory pathway from brainstem through thalamus. PLOS (Biology), 13:e1002253
Deschênes M, Takatoh J, Kurnikova A, Moore JD, Demers M, Elbaz M, Furuta T, Wang F, Kleinfeld D (2016) Inhibition, not excitation, drives rhythmic whisking. Neuron 90: 374-387.
orofacial behaviors, whisking, vibrissa, neuronal oscillators
2601 Chemin de la Canardière