Novelty representation on behavioural timescales by atypical neurons of the hippocampus

Conférence du Centre de recherche CERVO
Date & Time: 
Friday, January 12, 2024 - 11:00
Mark Cembrowski

Assistant Professor, Dept. of Cellular and Physiological Sciences, UBC
Investigator, Djavad Mowafaghian Centre for Brain Health, UBC
Associate Member, School of Biomedical Engineering, UBC
Associate Member, Dept. of Mathematics, UBC
Michael Smith Health Research BC Scholar
Associate Director, Graduate Program in Neuroscience, UBC


The hippocampus is often conceptualized as a cognitive map, wherein pyramidal cell activity can represent specific physical and mental properties. Recent results have illustrated that a region of the hippocampus termed the subiculum has a variety of distinct excitatory cell types, suggesting potential specialized cellular roles within this broad cognitive map framework. Here, we reveal and analyze a sparse non-pyramidal excitatory cell type in the subiculum, and discover that this cell type deviates substantially from classical structural and functional properties of pyramidal cells. Strikingly, this cell type selectively exhibits novelty-associated activity across multiple behavioural timescales (from seconds to months), and can control novelty-associated behavioural phenotypes. Our work suggests that distinct subtypes of excitatory neurons in the subiculum are specialized for fundamentally different types of cognitive maps.

Centre de recherche CERVO Brain Research Centre, 2601, de la Canardière Québec (Québec) CANADA G1J 2G3

Funding / Support / Partners

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