Paul Dutchak, M.Sc., Ph.D.
Investigating Neurometabolic Pathways involved in Brain Health and Disease.
Dr. Paul Dutchak's research program aims to understand the metabolic requirements for normal brain function and determine how genetic changes effect the regulation of metabolic pathways in the brain. Dr. Dutchak is particularly interested in developing a metabolic map of neurological disorders to better diagnose, and therapeutically target neurological diseases that are underscored by a dysregulation of metabolism, including: epilepsy, autism and tuberous sclerosis.
Dr. Dutchak's lab is currently studying an evolutionarily conserved amino acid sensing complex called GATOR1. Genetic mutations in this complex are associated with epilespy, autism and cancer in humans.
*Dr. Dutchak is currently looking for graduate students and post doctoral researchers to fill available positions in the lab. Only eligible and serious candidates will be considered.
Metabolic Networks Influencing Skeletal Muscle Fiber Composition. Bourdeau Julien I, Sephton CF, Dutchak PA. (2018) Front. Cell Dev. Biol. 6:125. doi: 10.3389/fcell.2018.00125
Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle. Dutchak PA, Estill-Terpack SJ, Plec AA, ... Deberardinis RJ, Yu Y, Tu BP. Cell Rep. 2018 May 15, 23(7): 1907–1914. doi: 10.1016/j.celrep.2018.04.058
Altering cellular differentiation and energy metabolism by the mTORC1 inhibitor NPRL2. Dutchak PA, Estill SJ, Tu BP. Mol Cancer Res April 1 2016 (14) doi: 10.1158/1557-3125.DEVBIOLCA15-B08
Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP. Cell Rep. 2015 Jul 21;12(3):371-9. doi: 10.1016/j.celrep.2015.06.042. Epub 2015 Jul 9. PMID:26166573
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, Kliewer SA. Cell. 2012 Feb 3;148(3):556-67. doi: 10.1016/j.cell.2011.11.062. PMID:22304921
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, Wan Y. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3143-8. doi: 10.1073/pnas.1200797109. Epub 2012 Feb 6. PMID:22315431
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. Cell Metab. 2007 Jun;5(6):415-25.PMID:17550777
- Bachelor of Science (B.Sc.): University of Saskatchewan, Department of Biochemistry
- Master of Science (M.Sc.): University of Saskatchewan, Department of Biochemistry
- Doctorate of Philosophy (Ph.D.): University of Texas Southwestern Medical Center at Dallas
- Post-doctoral Fellow: University of Texas Southwestern Medical Center at Dallas
2018-23 Natural Sciences and Engineering Research Council (NSERC/CRSNG) - Discovery Grant
2014-16 Cancer Prevention Research Institute of Texas -Training Grant
metabolism, cell signaling, translation, epilepsy, neurodegeneration
2601 Chemin de la Canardière