Publications | Cervo Brain Research Centre

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2022

“A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models.”, J Neurosci, vol. 42, no. 10, pp. 1930-1944, 2022.

A. Dedek, Xu, J., Lorenzo, L. - E., Godin, A. G., Kandegedara, C. M., Glavina, G., Landrigan, J. A., Lombroso, P. J., De Koninck, Y., Tsai, E. C., and Hildebrand, M. E., “Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain.”, Brain, vol. 145, no. 3, pp. 1124-1138, 2022.

2020

F. Ferrini, Perez-Sanchez, J., Ferland, S., Lorenzo, L. - E., Godin, A. G., Plasencia-Fernandez, I., Cottet, M., Castonguay, A., Wang, F., Salio, C., Doyon, N., Merighi, A., and De Koninck, Y., “Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization.”, Nat Commun, vol. 11, no. 1, p. 3935, 2020.

L. - E. Lorenzo, Godin, A. G., Ferrini, F., Bachand, K., Plasencia-Fernandez, I., Labrecque, S., Girard, A. A., Boudreau, D., Kianicka, I., Gagnon, M., Doyon, N., Ribeiro-da-Silva, A., and De Koninck, Y., “Enhancing neuronal chloride extrusion rescues α2/α3 GABA-mediated analgesia in neuropathic pain.”, Nat Commun, vol. 11, no. 1, p. 869, 2020.

W. Dong, Jin, S. Chih, Allocco, A., Zeng, X., Sheth, A. H., Panchagnula, S., Castonguay, A., Lorenzo, L. - E., Islam, B., Brindle, G., Bachand, K., Hu, J., Sularz, A., Gaillard, J., Choi, J., Dunbar, A., Nelson-Williams, C., Kiziltug, E., Furey, C. Gavankar, Conine, S., Duy, P. Q., Kundishora, A. J., Loring, E., Li, B., Lu, Q., Zhou, G., Liu, W., Li, X., Sierant, M. C., Mane, S., Castaldi, C., López-Giráldez, F., Knight, J. R., Sekula, R. F., J Simard, M., Eskandar, E. N., Gottschalk, C., Moliterno, J., Günel, M., Gerrard, J. L., Dib-Hajj, S., Waxman, S. G., Barker, F. G., Alper, S. L., Chahine, M., Haider, S., De Koninck, Y., Lifton, R. P., and Kahle, K. T., “Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia.”, iScience, vol. 23, no. 10, p. 101552, 2020.

2019

J. C. S. Mapplebeck, Lorenzo, L. - E., Lee, K. Yeop, Gauthier, C., Muley, M. M., De Koninck, Y., Prescott, S. A., and Salter, M. W., “Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.”, Cell Rep, vol. 28, no. 3, pp. 590-596.e4, 2019.

A. Dedek, Xu, J., Kandegedara, C. M., Lorenzo, L. - E., Godin, A. G., De Koninck, Y., Lombroso, P. J., Tsai, E. C., and Hildebrand, M. E., “Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.”, Brain, vol. 142, no. 6, pp. 1535-1546, 2019.

M. Richner, Pallesen, L. T., Ulrichsen, M., Poulsen, E. T., Holm, T. H., Login, H., Castonguay, A., Lorenzo, L. - E., Gonçalves, N. P., Andersen, O. M., Lykke-Hartmann, K., Enghild, J. J., Rønn, L. C. B., Malik, I. J., De Koninck, Y., Bjerrum, O. J., Vægter, C. B., and Nykjær, A., “Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain.”, Sci Adv, vol. 5, no. 6, p. eaav9946, 2019.

2017

F. Ferrini, Lorenzo, L. - E., Godin, A. G., Le Quang, M., and De Koninck, Y., “Enhancing KCC2 function counteracts morphine-induced hyperalgesia.”, Sci Rep, vol. 7, no. 1, p. 3870, 2017.

M. Gagnon, Bergeron, M. J., Perez-Sanchez, J., Plasencia-Fernandez, I., Lorenzo, L. - E., Godin, A. G., Castonguay, A., Bonin, R. P., and De Koninck, Y., “Reply to The small molecule CLP257 does not modify activity of the K-Cl co-transporter KCC2 but does potentiate GABA receptor activity.”, Nat Med, vol. 23, no. 12, pp. 1396-1398, 2017.

S. Echeverry, Shi, X. Qun, Yang, M., Huang, H., Wu, Y. C., Lorenzo, L. - E., Perez-Sanchez, J., Bonin, R. P., De Koninck, Y., and Zhang, J., “Spinal microglia are required for long-term maintenance of neuropathic pain.”, Pain, vol. 158, no. 9, pp. 1792-1801, 2017.

J. Perez-Sanchez, Lorenzo, L. - E., Lecker, I., Zurek, A. A., Labrakakis, C., Bridgwater, E. M., Orser, B. A., De Koninck, Y., and Bonin, R. P., “α5GABA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia.”, J Neurosci Res, vol. 95, no. 6, pp. 1307-1318, 2017.

2016

L. Binan, Mazzaferri, J., Choquet, K., Lorenzo, L. - E., Wang, Y. Chang, Affar, E. Bachir, De Koninck, Y., Ragoussis, J., Kleinman, C. L., and Costantino, S., “Live single-cell laser tag.”, Nat Commun, vol. 7, p. 11636, 2016.

2014

L. - E. Lorenzo, Godin, A. G., Wang, F., St-Louis, M., Carbonetto, S., Wiseman, P. W., Ribeiro-da-Silva, A., and De Koninck, Y., “Gephyrin clusters are absent from small diameter primary afferent terminals despite the presence of GABA(A) receptors.”, J Neurosci, vol. 34, no. 24, pp. 8300-17, 2014.

L. - E. Lorenzo, Magnussen, C., Bailey, A. L., St Louis, M., De Koninck, Y., and Ribeiro-da-Silva, A., “Spatial and temporal pattern of changes in the number of GAD65-immunoreactive inhibitory terminals in the rat superficial dorsal horn following peripheral nerve injury.”, Mol Pain, vol. 10, p. 57, 2014.

2013

F. Ferrini, Trang, T., Mattioli, T. - A. M., Laffray, S., Del'Guidice, T., Lorenzo, L. - E., Castonguay, A., Doyon, N., Zhang, W., Godin, A. G., Mohr, D., Beggs, S., Vandal, K., Beaulieu, J. - M., Cahill, C. M., Salter, M. W., and De Koninck, Y., “Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.”, Nat Neurosci, vol. 16, no. 2, pp. 183-92, 2013.

2011

A. G. Godin, Costantino, S., Lorenzo, L. - E., Swift, J. L., Sergeev, M., Ribeiro-da-Silva, A., De Koninck, Y., and Wiseman, P. W., “Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis.”, Proc Natl Acad Sci U S A, vol. 108, no. 17, pp. 7010-5, 2011.

2009

C. Labrakakis, Lorenzo, L. - E., Bories, C., Ribeiro-da-Silva, A., and De Koninck, Y., “Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn.”, Mol Pain, vol. 5, p. 24, 2009.

2008

L. - E. Lorenzo, Ramien, M., St Louis, M., De Koninck, Y., and Ribeiro-da-Silva, A., “Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat.”, J Comp Neurol, vol. 508, no. 4, pp. 592-604, 2008.

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