Publications
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Filters: Author is Mohamed Chahine [Clear All Filters]
, “Na1.5 knockout in iPSCs: a novel approach to study Na1.5 variants in a human cardiomyocyte environment.”, Sci Rep, vol. 11, no. 1, p. 17168, 2021.
, “Novel G1481V and Q1491H SCN5A Mutations Linked to Long QT Syndrome Destabilize the Nav1.5 Inactivation State.”, CJC Open, vol. 3, no. 3, pp. 256-266, 2021.
, “R1617Q epilepsy mutation slows Na 1.6 sodium channel inactivation and increases the persistent current and neuronal firing.”, J Physiol, vol. 599, no. 5, pp. 1651-1664, 2021.
, “Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia.”, iScience, vol. 23, no. 10, p. 101552, 2020.
, “Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides.”, Sci Rep, vol. 9, no. 1, p. 1078, 2019.
, “A204E mutation in Na1.4 DIS3 exerts gain- and loss-of-function effects that lead to periodic paralysis combining hyper- with hypo-kalaemic signs.”, Sci Rep, vol. 8, no. 1, p. 16681, 2018.
, “Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.”, PLoS One, vol. 13, no. 12, p. e0208321, 2018.
, “A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy.”, Sci Rep, vol. 8, no. 1, p. 13804, 2018.
, “A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Na1.5 Gating Pores.”, Front Cardiovasc Med, vol. 5, p. 139, 2018.
, “Biophysical characterization of the Varroa destructor NaV1 sodium channel and its affinity for τ-fluvalinate insecticide.”, FASEB J, vol. 31, no. 7, pp. 3066-3071, 2017.
, “Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes.”, Can J Cardiol, vol. 33, no. 2, pp. 269-278, 2017.
, “Induced pluripotent stem-cell-derived cardiomyocytes: cardiac applications, opportunities, and challenges.”, Can J Physiol Pharmacol, vol. 95, no. 10, pp. 1108-1116, 2017.
, “Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.”, Handb Exp Pharmacol, 2017.
, “Metaflumizone inhibits the honeybee NaV 1 channel by targeting recovery from slow inactivation.”, FEBS Lett, 2017.
, “Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C.”, Handb Exp Pharmacol, 2017.
, “Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4.”, J Gen Physiol, vol. 148, no. 2, pp. 133-45, 2016.
, “Editorial: Recent Advances in Voltage-Gated Sodium Channels, their Pharmacology and Related Diseases.”, Front Pharmacol, vol. 7, p. 20, 2016.
, “Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea-pigs.”, J Physiol, vol. 594, no. 21, pp. 6175-6187, 2016.
, “A recessive Nav1.4 mutation underlies congenital myasthenic syndrome with periodic paralysis.”, Neurology, vol. 86, no. 2, pp. 161-9, 2016.
, “Characterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticides.”, Sci Rep, vol. 5, p. 12475, 2015.
, “Differential modulation of Nav1.7 and Nav1.8 channels by antidepressant drugs.”, Eur J Pharmacol, vol. 764, pp. 395-403, 2015.
, “Effects of amlodipine and perindoprilate on the structure and function of mitochondria in ventricular cardiomyocytes during ischemia-reperfusion in the pig.”, Fundam Clin Pharmacol, vol. 29, no. 1, pp. 21-30, 2015.
, “Gating pore current is a novel biophysical defect of Nav1.5 mutations associated with unusual cardiac arrhythmias and dilation.”, Future Cardiol, vol. 11, no. 3, pp. 287-91, 2015.
, “Gating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy.”, Channels (Austin), vol. 9, no. 3, pp. 139-44, 2015.
, “Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.”, J Gen Physiol, vol. 145, no. 2, pp. 93-106, 2015.
