Publications

2022

“Comparative Transcriptional Analyses in the Nucleus Accumbens Identifies RGS2 as a Key Mediator of Depression-Related Behavior.”, Biol Psychiatry, vol. 92, no. 12, pp. 942-951, 2022.

2021

“Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum.”, iScience, vol. 24, no. 10, p. 103169, 2021.

2020

B. Labonte, Abdallah, K., Maussion, G., Yerko, V., Yang, J., Bittar, T., Quessy, F., Golden, S. A., Navarro, L., Checknita, D., Gigek, C., Lopez, J. Pablo, Neve, R. L., Russo, S. J., Tremblay, R. E., Côté, G., Meaney, M. J., Mechawar, N., Nestler, E. J., and Turecki, G., “Regulation of impulsive and aggressive behaviours by a novel lncRNA.”, Mol Psychiatry, 2020.

J. R. Scarpa, Fatma, M., Loh, Y. - H. E., Traore, S. Romaric, Stefan, T., Chen, T. - H., Nestler, E. J., and Labonte, B., “Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models.”, Biol Psychiatry, vol. 88, no. 2, pp. 159-168, 2020.

2019

H. Kronman, Richter, F., Labonte, B., Chandra, R., Zhao, S., Hoffman, G., Lobo, M. Kay, Schadt, E. E., and Nestler, E. J., “Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons.”, Sci Rep, vol. 9, no. 1, p. 8350, 2019.

B. Labonte, Jeong, Y. Ha, Parise, E., Issler, O., Fatma, M., Engmann, O., Cho, K. - A., Neve, R., Nestler, E. J., and Koo, J. Wook, “Gadd45b mediates depressive-like role through DNA demethylation.”, Sci Rep, vol. 9, no. 1, p. 4615, 2019.

C. Nasca, Menard, C., Hodes, G., Bigio, B., Peña, C., Lorsch, Z., Zelli, D., Ferris, A., Kana, V., Purushothaman, I., Dobbin, J., Nassim, M., DeAngelis, P., Merad, M., Rasgon, N., Meaney, M., Nestler, E. J., McEwen, B. S., and Russo, S. J., “Multidimensional Predictors of Susceptibility and Resilience to Social Defeat Stress.”, Biol Psychiatry, vol. 86, no. 6, pp. 483-491, 2019.

Z. S. Lorsch, Hamilton, P. J., Ramakrishnan, A., Parise, E. M., Salery, M., Wright, W. J., Lepack, A. E., Mews, P., Issler, O., McKenzie, A., Zhou, X., Parise, L. F., Pirpinias, S. T., Torres, I. Ortiz, Kronman, H. G., Montgomery, S. E., Loh, Y. - H. Eddie, Labonte, B., Conkey, A., Symonds, A. E., Neve, R. L., Turecki, G., Maze, I., Dong, Y., Zhang, B., Shen, L., Bagot, R. C., and Nestler, E. J., “Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.”, Nat Neurosci, vol. 22, no. 9, pp. 1413-1423, 2019.

C. Jiang, Lin, W. - J., Labonte, B., Tamminga, C. A., Turecki, G., Nestler, E. J., Russo, S. J., and Salton, S. R., “VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine.”, Neuropsychopharmacology, vol. 44, no. 5, pp. 971-981, 2019.

2018

H. Aleyasin, Flanigan, M. E., Golden, S. A., Takahashi, A., Menard, C., Pfau, M. L., Multer, J., Pina, J., McCabe, K. A., Bhatti, N., Hodes, G. E., Heshmati, M., Neve, R. L., Nestler, E. J., Heller, E. A., and Russo, S. J., “Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression.”, J Neurosci, vol. 38, no. 26, pp. 5913-5924, 2018.

B. Labonte, Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y. - H. E., Cahill, M., Lorsch, Z. S., Hamilton, P. J., Calipari, E. S., Hodes, G. E., Issler, O., Kronman, H., Pfau, M., Obradovic, A. L. J., Dong, Y., Neve, R. L., Russo, S., Kasarskis, A., Tamminga, C., Mechawar, N., Turecki, G., Zhang, B., Shen, L., and Nestler, E. J., “Corrigendum: Sex-specific transcriptional signatures in human depression.”, Nat Med, vol. 24, no. 4, p. 525, 2018.

Z. S. Lorsch, Loh, Y. - H. Eddie, Purushothaman, I., Walker, D. M., Parise, E. M., Salery, M., Cahill, M. E., Hodes, G. E., Pfau, M. L., Kronman, H., Hamilton, P. J., Issler, O., Labonte, B., Symonds, A. E., Zucker, M., Zhang, T. Yuan, Meaney, M. J., Russo, S. J., Shen, L., Bagot, R. C., and Nestler, E. J., “Estrogen receptor α drives pro-resilient transcription in mouse models of depression.”, Nat Commun, vol. 9, no. 1, p. 1116, 2018.

2017

O. Engmann, Labonte, B., Mitchell, A., Bashtrykov, P., Calipari, E. S., Rosenbluh, C., Loh, Y. - H. E., Walker, D. M., Burek, D., Hamilton, P. J., Issler, O., Neve, R. L., Turecki, G., Hurd, Y., Chess, A., Shen, L., Mansuy, I., Jeltsch, A., Akbarian, S., and Nestler, E. J., “Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.”, Biol Psychiatry, 2017.

A. Takahashi, Chung, J. - R., Zhang, S., Zhang, H., Grossman, Y., Aleyasin, H., Flanigan, M. E., Pfau, M. L., Menard, C., Dumitriu, D., Hodes, G. E., McEwen, B. S., Nestler, E. J., Han, M. - H., and Russo, S. J., “Establishment of a repeated social defeat stress model in female mice.”, Sci Rep, vol. 7, no. 1, p. 12838, 2017.

R. C. Bagot, Cates, H. M., Purushothaman, I., Vialou, V., Heller, E. A., Yieh, L., Labonte, B., Peña, C. J., Shen, L., Wittenberg, G. M., and Nestler, E. J., “Ketamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles.”, Biol Psychiatry, vol. 81, no. 4, pp. 285-295, 2017.

Y. Jiang, Loh, Y. - H. Eddie, Rajarajan, P., Hirayama, T., Liao, W., Kassim, B. S., Javidfar, B., Hartley, B. J., Kleofas, L., Park, R. B., Labonte, B., Ho, S. - M., Chandrasekaran, S., Do, C., Ramirez, B. R., Peter, C. J., W, J. T. C., Safaie, B. M., Morishita, H., Roussos, P., Nestler, E. J., Schaefer, A., Tycko, B., Brennand, K. J., Yagi, T., Shen, L., and Akbarian, S., “The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.”, Nat Genet, vol. 49, no. 8, pp. 1239-1250, 2017.

J. Pablo Lopez, Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., Han, M. - H., Foster, J., Frey, B. N., Soares, C. N., Müller, D. J., Farzan, F., Leri, F., MacQueen, G. M., Feilotter, H., Tyryshkin, K., Evans, K. R., Giacobbe, P., Blier, P., Lam, R. W., Milev, R., Parikh, S. V., Rotzinger, S., Strother, S. C., Lewis, C. M., Aitchison, K. J., Wittenberg, G. M., Mechawar, N., Nestler, E. J., Uher, R., Kennedy, S. H., and Turecki, G., “MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.”, Nat Commun, vol. 8, p. 15497, 2017.

B. Labonte, Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y. - H. E., Cahill, M., Lorsch, Z. S., Hamilton, P. J., Calipari, E. S., Hodes, G. E., Issler, O., Kronman, H., Pfau, M., Obradovic, A. L. J., Dong, Y., Neve, R. L., Russo, S., Kazarskis, A., Tamminga, C., Mechawar, N., Turecki, G., Zhang, B., Shen, L., and Nestler, E. J., “Sex-specific transcriptional signatures in human depression.”, Nat Med, vol. 23, no. 9, pp. 1102-1111, 2017.

G. E. Hodes, Walker, D. M., Labonte, B., Nestler, E. J., and Russo, S. J., “Understanding the epigenetic basis of sex differences in depression.”, J Neurosci Res, vol. 95, no. 1-2, pp. 692-702, 2017.

2016

D. D. Kiraly, Walker, D. M., Calipari, E. S., Labonte, B., Issler, O., Peña, C. J., Ribeiro, E. A., Russo, S. J., and Nestler, E. J., “Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine.”, Sci Rep, vol. 6, p. 35455, 2016.

J. Wook Koo, Labonte, B., Engmann, O., Calipari, E. S., Juarez, B., Lorsch, Z., Walsh, J. J., Friedman, A. K., Yorgason, J. T., Han, M. - H., and Nestler, E. J., “Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors.”, Biol Psychiatry, vol. 80, no. 6, pp. 469-78, 2016.

2015

H. Sun, Damez-Werno, D. M., Scobie, K. N., Shao, N. - Y., Dias, C., Rabkin, J., Koo, J. Wook, Korb, E., Bagot, R. C., Ahn, F. H., Cahill, M. E., Labonte, B., Mouzon, E., Heller, E. A., Cates, H., Golden, S. A., Gleason, K., Russo, S. J., Andrews, S., Neve, R., Kennedy, P. J., Maze, I., Dietz, D. M., C Allis, D., Turecki, G., Varga-Weisz, P., Tamminga, C., Shen, L., and Nestler, E. J., “ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior.”, Nat Med, vol. 21, no. 10, pp. 1146-53, 2015.

J. Wook Koo, Mazei-Robison, M. S., LaPlant, Q., Egervari, G., Braunscheidel, K. M., Adank, D. N., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D. M., Ribeiro, E., Peña, C. Jensen, Walker, D., Bagot, R. C., Cahill, M. E., Anderson, S. Ann R., Labonte, B., Hodes, G. E., Browne, H., Chadwick, B., Robison, A. J., Vialou, V. F., Dias, C., Lorsch, Z., Mouzon, E., Lobo, M. Kay, Dietz, D. M., Russo, S. J., Neve, R. L., Hurd, Y. L., and Nestler, E. J., “Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area.”, Nat Neurosci, vol. 18, no. 3, pp. 415-22, 2015.

J. Feng, Shao, N., Szulwach, K. E., Vialou, V., Huynh, J., Zhong, C., Le, T., Ferguson, D., Cahill, M. E., Li, Y., Koo, J. Wook, Ribeiro, E., Labonte, B., Laitman, B. M., Estey, D., Stockman, V., Kennedy, P., Couroussé, T., Mensah, I., Turecki, G., Faull, K. F., Ming, G. -li, Song, H., Fan, G., Casaccia, P., Shen, L., Jin, P., and Nestler, E. J., “Role of Tet1 and 5-hydroxymethylcytosine in cocaine action.”, Nat Neurosci, vol. 18, no. 4, pp. 536-44, 2015.

G. E. Hodes, Pfau, M. L., Purushothaman, I., H Ahn, F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., Menard, C., Aleyasin, H., Koo, J. Wook, Lorsch, Z. S., Feng, J., Heshmati, M., Wang, M., Turecki, G., Neve, R., Zhang, B., Shen, L., Nestler, E. J., and Russo, S. J., “Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.”, J Neurosci, vol. 35, no. 50, pp. 16362-76, 2015.

Publications

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