Publications

2023

“Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis.”, PLoS One, vol. 18, no. 5, p. e0285263, 2023.

2022

“Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.”, Nat Commun, vol. 13, no. 1, p. 164, 2022.

2021

“Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum.”, iScience, vol. 24, no. 10, p. 103169, 2021.

2020

K. A. Dudek, Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Perez, C. Ferrer, Golden, S. A., Tamminga, C., Turecki, G., Mechawar, N., Russo, S. J., and Chow, Y. W., “Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression.”, Proc Natl Acad Sci U S A, vol. 117, no. 6, pp. 3326-3336, 2020.

B. Labonte, Abdallah, K., Maussion, G., Yerko, V., Yang, J., Bittar, T., Quessy, F., Golden, S. A., Navarro, L., Checknita, D., Gigek, C., Lopez, J. Pablo, Neve, R. L., Russo, S. J., Tremblay, R. E., Côté, G., Meaney, M. J., Mechawar, N., Nestler, E. J., and Turecki, G., “Regulation of impulsive and aggressive behaviours by a novel lncRNA.”, Mol Psychiatry, 2020.

2019

Z. S. Lorsch, Hamilton, P. J., Ramakrishnan, A., Parise, E. M., Salery, M., Wright, W. J., Lepack, A. E., Mews, P., Issler, O., McKenzie, A., Zhou, X., Parise, L. F., Pirpinias, S. T., Torres, I. Ortiz, Kronman, H. G., Montgomery, S. E., Loh, Y. - H. Eddie, Labonte, B., Conkey, A., Symonds, A. E., Neve, R. L., Turecki, G., Maze, I., Dong, Y., Zhang, B., Shen, L., Bagot, R. C., and Nestler, E. J., “Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.”, Nat Neurosci, vol. 22, no. 9, pp. 1413-1423, 2019.

C. Jiang, Lin, W. - J., Labonte, B., Tamminga, C. A., Turecki, G., Nestler, E. J., Russo, S. J., and Salton, S. R., “VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine.”, Neuropsychopharmacology, vol. 44, no. 5, pp. 971-981, 2019.

2018

M. Heshmati, Aleyasin, H., Menard, C., Christoffel, D. J., Flanigan, M. E., Pfau, M. L., Hodes, G. E., Lepack, A. E., Bicks, L. K., Takahashi, A., Chandra, R., Turecki, G., Lobo, M. Kay, Maze, I., Golden, S. A., and Russo, S. J., “Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.”, Proc Natl Acad Sci U S A, vol. 115, no. 5, pp. 1111-1116, 2018.

B. Labonte, Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y. - H. E., Cahill, M., Lorsch, Z. S., Hamilton, P. J., Calipari, E. S., Hodes, G. E., Issler, O., Kronman, H., Pfau, M., Obradovic, A. L. J., Dong, Y., Neve, R. L., Russo, S., Kasarskis, A., Tamminga, C., Mechawar, N., Turecki, G., Zhang, B., Shen, L., and Nestler, E. J., “Corrigendum: Sex-specific transcriptional signatures in human depression.”, Nat Med, vol. 24, no. 4, p. 525, 2018.

2017

P. - E. Lutz, Tanti, A., Gasecka, A., Barnett-Burns, S., Kim, J. J., Zhou, Y., Chen, G. G., Wakid, M., Shaw, M., Almeida, D., Chay, M. - A., Yang, J., Larivière, V., M'Boutchou, M. - N., van Kempen, L. C., Yerko, V., Prud'homme, J., Davoli, M. Antonietta, Vaillancourt, K., Théroux, J. - F., Bramoullé, A., Zhang, T. - Y., Meaney, M. J., Ernst, C., Côté, D. C., Mechawar, N., and Turecki, G., “Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence.”, Am J Psychiatry, p. appiajp201716111286, 2017.

O. Engmann, Labonte, B., Mitchell, A., Bashtrykov, P., Calipari, E. S., Rosenbluh, C., Loh, Y. - H. E., Walker, D. M., Burek, D., Hamilton, P. J., Issler, O., Neve, R. L., Turecki, G., Hurd, Y., Chess, A., Shen, L., Mansuy, I., Jeltsch, A., Akbarian, S., and Nestler, E. J., “Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.”, Biol Psychiatry, 2017.

J. Pablo Lopez, Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., Han, M. - H., Foster, J., Frey, B. N., Soares, C. N., Müller, D. J., Farzan, F., Leri, F., MacQueen, G. M., Feilotter, H., Tyryshkin, K., Evans, K. R., Giacobbe, P., Blier, P., Lam, R. W., Milev, R., Parikh, S. V., Rotzinger, S., Strother, S. C., Lewis, C. M., Aitchison, K. J., Wittenberg, G. M., Mechawar, N., Nestler, E. J., Uher, R., Kennedy, S. H., and Turecki, G., “MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.”, Nat Commun, vol. 8, p. 15497, 2017.

B. Labonte, Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y. - H. E., Cahill, M., Lorsch, Z. S., Hamilton, P. J., Calipari, E. S., Hodes, G. E., Issler, O., Kronman, H., Pfau, M., Obradovic, A. L. J., Dong, Y., Neve, R. L., Russo, S., Kazarskis, A., Tamminga, C., Mechawar, N., Turecki, G., Zhang, B., Shen, L., and Nestler, E. J., “Sex-specific transcriptional signatures in human depression.”, Nat Med, vol. 23, no. 9, pp. 1102-1111, 2017.

C. Menard, Pfau, M. L., Hodes, G. E., Kana, V., Wang, V. X., Bouchard, S., Takahashi, A., Flanigan, M. E., Aleyasin, H., LeClair, K. B., Janssen, W. G., Labonte, B., Parise, E. M., Lorsch, Z. S., Golden, S. A., Heshmati, M., Tamminga, C., Turecki, G., Campbell, M., Fayad, Z. A., Tang, C. Ying, Merad, M., and Russo, S. J., “Social stress induces neurovascular pathology promoting depression.”, Nat Neurosci, vol. 20, no. 12, pp. 1752-1760, 2017.

2015

H. Sun, Damez-Werno, D. M., Scobie, K. N., Shao, N. - Y., Dias, C., Rabkin, J., Koo, J. Wook, Korb, E., Bagot, R. C., Ahn, F. H., Cahill, M. E., Labonte, B., Mouzon, E., Heller, E. A., Cates, H., Golden, S. A., Gleason, K., Russo, S. J., Andrews, S., Neve, R., Kennedy, P. J., Maze, I., Dietz, D. M., C Allis, D., Turecki, G., Varga-Weisz, P., Tamminga, C., Shen, L., and Nestler, E. J., “ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior.”, Nat Med, vol. 21, no. 10, pp. 1146-53, 2015.

H. Galfalvy, Haghighi, F., Hodgkinson, C., Goldman, D., Oquendo, M. A., Burke, A., Huang, Y. - Y., Giegling, I., Rujescu, D., Bureau, A., Turecki, G., and J Mann, J., “A genome-wide association study of suicidal behavior.”, Am J Med Genet B Neuropsychiatr Genet, vol. 168, no. 7, pp. 557-63, 2015.

J. A. Gross, Bureau, A., Croteau, J., Galfalvy, H., Oquendo, M. A., Haghighi, F., Mérette, C., Giegling, I., Hodgkinson, C., Goldman, D., Rujescu, D., J Mann, J., and Turecki, G., “A genome-wide copy number variant study of suicidal behavior.”, PLoS One, vol. 10, no. 5, p. e0128369, 2015.

J. Feng, Shao, N., Szulwach, K. E., Vialou, V., Huynh, J., Zhong, C., Le, T., Ferguson, D., Cahill, M. E., Li, Y., Koo, J. Wook, Ribeiro, E., Labonte, B., Laitman, B. M., Estey, D., Stockman, V., Kennedy, P., Couroussé, T., Mensah, I., Turecki, G., Faull, K. F., Ming, G. -li, Song, H., Fan, G., Casaccia, P., Shen, L., Jin, P., and Nestler, E. J., “Role of Tet1 and 5-hydroxymethylcytosine in cocaine action.”, Nat Neurosci, vol. 18, no. 4, pp. 536-44, 2015.

G. E. Hodes, Pfau, M. L., Purushothaman, I., H Ahn, F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., Menard, C., Aleyasin, H., Koo, J. Wook, Lorsch, Z. S., Feng, J., Heshmati, M., Wang, M., Turecki, G., Neve, R., Zhang, B., Shen, L., Nestler, E. J., and Russo, S. J., “Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.”, J Neurosci, vol. 35, no. 50, pp. 16362-76, 2015.

2014

A. J. Robison, Vialou, V., Sun, H. - S., Labonte, B., Golden, S. A., Dias, C., Turecki, G., Tamminga, C., Russo, S., Mazei-Robison, M., and Nestler, E. J., “Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects.”, Neuropsychopharmacology, vol. 39, no. 5, pp. 1178-86, 2014.

J. Pablo Lopez, Lim, R., Cruceanu, C., Crapper, L., Fasano, C., Labonte, B., Maussion, G., Yang, J. P., Yerko, V., Vigneault, E., Mestikawy, S. El, Mechawar, N., Pavlidis, P., and Turecki, G., “miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.”, Nat Med, vol. 20, no. 7, pp. 764-8, 2014.

J. Pablo Lopez, Fiori, L. M., Gross, J. A., Labonte, B., Yerko, V., Mechawar, N., and Turecki, G., “Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.”, Int J Neuropsychopharmacol, vol. 17, no. 1, pp. 23-32, 2014.

2013

J. A. Gross, Fiori, L. M., Labonte, B., Lopez, J. Pablo, and Turecki, G., “Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.”, J Psychiatr Res, vol. 47, no. 4, pp. 513-9, 2013.

T. Yuan Zhang, Labonte, B., Wen, X. Lan, Turecki, G., and Meaney, M. J., “Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans.”, Neuropsychopharmacology, vol. 38, no. 1, pp. 111-23, 2013.

B. Labonte, Suderman, M., Maussion, G., Lopez, J. Pablo, Navarro-Sánchez, L., Yerko, V., Mechawar, N., Szyf, M., Meaney, M. J., and Turecki, G., “Genome-wide methylation changes in the brains of suicide completers.”, Am J Psychiatry, vol. 170, no. 5, pp. 511-20, 2013.

Publications

Funding / Support / Partners