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Filters: Keyword is Amyotrophic Lateral Sclerosis [Clear All Filters]
, “FUS contributes to mTOR-dependent inhibition of translation.”, J Biol Chem, vol. 295, no. 52, pp. 18459-18473, 2020.
, “Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis.”, Mol Ther, vol. 22, no. 3, pp. 498-510, 2014.
, “Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.”, Hum Mol Genet, vol. 22, no. 19, pp. 3947-59, 2013.
, “Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.”, Neuron, vol. 80, no. 1, pp. 80-96, 2013.
, “Ablation of proliferating cells in the CNS exacerbates motor neuron disease caused by mutant superoxide dismutase.”, PLoS One, vol. 7, no. 4, p. e34932, 2012.
, “Abnormal regenerative responses and impaired axonal outgrowth after nerve crush in TDP-43 transgenic mouse models of amyotrophic lateral sclerosis.”, J Neurosci, vol. 32, no. 50, pp. 18186-95, 2012.
, “Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS.”, Proc Natl Acad Sci U S A, vol. 109, no. 14, pp. 5505-10, 2012.
, “Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models.”, Neuroscience, vol. 209, pp. 136-43, 2012.
, “TDP-43 aggregation in neurodegeneration: are stress granules the key?”, Brain Res, vol. 1462, pp. 16-25, 2012.
, “ALS pathogenesis: recent insights from genetics and mouse models.”, Prog Neuropsychopharmacol Biol Psychiatry, vol. 35, no. 2, pp. 363-9, 2011.
, “Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.”, J Exp Med, vol. 208, no. 12, pp. 2429-47, 2011.
, “Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.”, Brain, vol. 134, no. Pt 9, pp. 2610-26, 2011.
, “TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.”, Mol Cell Biol, vol. 31, no. 5, pp. 1098-108, 2011.
, “Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice.”, Exp Neurol, vol. 228, no. 1, pp. 69-79, 2011.
, “Distinct biochemical signatures characterize peripherin isoform expression in both traumatic neuronal injury and motor neuron disease.”, J Neurochem, vol. 114, no. 4, pp. 1177-92, 2010.
, “Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice.”, J Neuropathol Exp Neurol, vol. 69, no. 10, pp. 1044-56, 2010.
, “Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS.”, J Neurochem, vol. 113, no. 5, pp. 1188-99, 2010.
, “Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS.”, J Neurochem, vol. 115, no. 5, pp. 1102-11, 2010.
, “Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.”, Nat Neurosci, vol. 13, no. 11, pp. 1396-403, 2010.
, “Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis.”, Proc Natl Acad Sci U S A, vol. 106, no. 51, pp. 21777-82, 2009.
, “Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells.”, Glia, vol. 57, no. 10, pp. 1130-42, 2009.
, “Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.”, Exp Neurol, vol. 220, no. 2, pp. 267-75, 2009.
, “Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.”, J Neurosci, vol. 28, no. 41, pp. 10234-44, 2008.
, “Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish.”, Hum Mol Genet, vol. 17, no. 17, pp. 2691-702, 2008.
, “ALS: astrocytes move in as deadly neighbors.”, Nat Neurosci, vol. 10, no. 5, pp. 535-7, 2007.
