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, “Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis.”, Mol Ther, vol. 22, no. 3, pp. 498-510, 2014.
, “Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.”, Hum Mol Genet, vol. 22, no. 19, pp. 3947-59, 2013.
, “Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.”, Neuron, vol. 80, no. 1, pp. 80-96, 2013.
, “Ablation of proliferating cells in the CNS exacerbates motor neuron disease caused by mutant superoxide dismutase.”, PLoS One, vol. 7, no. 4, p. e34932, 2012.
, “Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS.”, Proc Natl Acad Sci U S A, vol. 109, no. 14, pp. 5505-10, 2012.
, “Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models.”, Neuroscience, vol. 209, pp. 136-43, 2012.
, “ALS pathogenesis: recent insights from genetics and mouse models.”, Prog Neuropsychopharmacol Biol Psychiatry, vol. 35, no. 2, pp. 363-9, 2011.
, “Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.”, PLoS One, vol. 6, no. 7, p. e22031, 2011.
, “Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice.”, Exp Neurol, vol. 228, no. 1, pp. 69-79, 2011.
, “Extracellular mutant SOD1 induces microglial-mediated motoneuron injury.”, Glia, vol. 58, no. 2, pp. 231-43, 2010.
, “Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice.”, J Neuropathol Exp Neurol, vol. 69, no. 10, pp. 1044-56, 2010.
, “Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS.”, J Neurochem, vol. 113, no. 5, pp. 1188-99, 2010.
, “Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS.”, J Neurochem, vol. 115, no. 5, pp. 1102-11, 2010.
, “Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.”, Nat Neurosci, vol. 13, no. 11, pp. 1396-403, 2010.
, “Wild-type human SOD1 overexpression does not accelerate motor neuron disease in mice expressing murine Sod1 G86R.”, Neurobiol Dis, vol. 40, no. 1, pp. 245-50, 2010.
, “Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells.”, Glia, vol. 57, no. 10, pp. 1130-42, 2009.
, “Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.”, Exp Neurol, vol. 220, no. 2, pp. 267-75, 2009.
, “A novel function for fragile X mental retardation protein in translational activation.”, PLoS Biol, vol. 7, no. 1, p. e16, 2009.
, “Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.”, J Neurosci, vol. 28, no. 41, pp. 10234-44, 2008.
, “The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS.”, FASEB J, vol. 22, no. 7, pp. 2476-87, 2008.
, “Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis.”, Proc Natl Acad Sci U S A, vol. 104, no. 7, pp. 2495-500, 2007.
, “Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS.”, Neurobiol Dis, vol. 26, no. 1, pp. 146-52, 2007.
, “Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation.”, J Neurochem, vol. 102, no. 1, pp. 170-8, 2007.
, “Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations.”, J Neurosci, vol. 26, no. 44, pp. 11397-402, 2006.
, “Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis.”, Nat Neurosci, vol. 9, no. 1, pp. 108-18, 2006.
