Publications

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2009
H. Huang, Millat, G., Rodriguez-Lafrasse, C., Rousson, R., Kugener, B., Chevalier, P., and Chahine, M., Biophysical characterization of a new SCN5A mutation S1333Y in a SIDS infant linked to long QT syndrome., FEBS Lett, vol. 583, no. 5, pp. 890-6, 2009.
M. Chahine, Cardiac metabolic state and Brugada syndrome: a link revealed., Circ Res, vol. 105, no. 8, pp. 721-3, 2009.
D. I. Keller, Grenier, J., Christé, G., Dubouloz, F., Osswald, S., Brink, M., Ficker, E., and Chahine, M., Characterization of novel KCNH2 mutations in type 2 long QT syndrome manifesting as seizures., Can J Cardiol, vol. 25, no. 8, pp. 455-62, 2009.
G. Millat, Kugener, B., Chevalier, P., Chahine, M., Huang, H., Malicier, D., Rodriguez-Lafrasse, C., and Rousson, R., Contribution of long-QT syndrome genetic variants in sudden infant death syndrome., Pediatr Cardiol, vol. 30, no. 4, pp. 502-9, 2009.
Q. Li, Huang, H., Liu, G., Lam, K., Rutberg, J., Green, M. S., Birnie, D. H., Lemery, R., Chahine, M., and Gollob, M. H., Gain-of-function mutation of Nav1.5 in atrial fibrillation enhances cellular excitability and lowers the threshold for action potential firing., Biochem Biophys Res Commun, vol. 380, no. 1, pp. 132-7, 2009.
O. Ramadan, Qu, Y., Wadgaonkar, R., Baroudi, G., Karnabi, E., Chahine, M., and Boutjdir, M., Phosphorylation of the consensus sites of protein kinase A on alpha1D L-type calcium channel., J Biol Chem, vol. 284, no. 8, pp. 5042-9, 2009.
2008
A. Chatelier, Dahllund, L., Eriksson, A., Krupp, J., and Chahine, M., Biophysical properties of human Na v1.7 splice variants and their regulation by protein kinase A., J Neurophysiol, vol. 99, no. 5, pp. 2241-50, 2008.
G. Christé, Chahine, M., Chevalier, P., and Pásek, M., Changes in action potentials and intracellular ionic homeostasis in a ventricular cell model related to a persistent sodium current in SCN5A mutations underlying LQT3., Prog Biophys Mol Biol, vol. 96, no. 1-3, pp. 281-93, 2008.
M. Israil Hossain, Iwasaki, H., Okochi, Y., Chahine, M., Higashijima, S., Nagayama, K., and Okamura, Y., Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases., J Biol Chem, vol. 283, no. 26, pp. 18248-59, 2008.
M. - T. Lin, Wu, M. - H., Chang, C. - C., Chiu, S. - N., Thériault, O., Huang, H., Christé, G., Ficker, E., and Chahine, M., In utero onset of long QT syndrome with atrioventricular block and spontaneous or lidocaine-induced ventricular tachycardia: compound effects of hERG pore region mutation and SCN5A N-terminus variant., Heart Rhythm, vol. 5, no. 11, pp. 1567-74, 2008.
G. Christé, Thériault, O., Chahine, M., Millat, G., Rodriguez-Lafrasse, C., Rousson, R., Deschênes, I., Ficker, E., and Chevalier, P., A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope., Heart Rhythm, vol. 5, no. 11, pp. 1577-86, 2008.
I. Six, Hermida, J. - S., Huang, H., Gouas, L., Fressart, V., Benammar, N., Hainque, B., Denjoy, I., Chahine, M., and Guicheney, P., The occurrence of Brugada syndrome and isolated cardiac conductive disease in the same family could be due to a single SCN5A mutation or to the accidental association of both diseases., Europace, vol. 10, no. 1, pp. 79-85, 2008.
M. Chahine, Qu, Y., Mancarella, S., and Boutjdir, M., Protein kinase C activation inhibits alpha1D L-type Ca channel: a single-channel analysis., Pflugers Arch, vol. 455, no. 5, pp. 913-9, 2008.
M. Chahine, Chatelier, A., Babich, O., and Krupp, J. J., Voltage-gated sodium channels in neurological disorders., CNS Neurol Disord Drug Targets, vol. 7, no. 2, pp. 144-58, 2008.

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