Real-time imaging of astrocyte response to quantum dots: in vivo screening model system for biocompatibility of nanoparticles.

Publication Type:

Journal Article

Authors:

Maysinger, Dusica; Behrendt, Maik; Lalancette-Hébert, Mélanie; Jasna Kriz

Source:

Nano Lett, Volume 7, Issue 8, p.2513-20 (2007)

Keywords:

Animals, Astrocytes, Cell Survival, Computer Systems, Microscopy, Fluorescence, Nanoparticles, PC12 Cells, Quantum Dots, Rats

Abstract:

<p>Astrocytes are the principle macroglial brain cells. They are activated by different stressors and brain injuries. Quantum dots (QDs) can cause oxidative stress. This study shows a real-time imaging of primary cortical cultures and assessment of QD-induced activation of astrocytes in the brains of transgenic mice with the luciferase gene driven by the murine astrocyte promoter. This approach may be widely applicable for assessing the astroglia/tissue response to nanoparticles in live animals.</p>