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Reconsolidation and the regulation of plasticity: moving beyond memory.

Publication Type:

Journal Article

Source:

Trends Neurosci, Volume 38, Issue 6, p.336-44 (2015)

Keywords:

Animals, Humans, Memory Consolidation, Neuronal Plasticity

Abstract:

Memory reconsolidation is a protein synthesis-dependent process that preserves, in some form, memories that have been destabilized through recall. Reconsolidation is a nearly universal phenomenon, occurring in a diverse array of species and learning tasks. The function of reconsolidation remains unclear but it has been proposed as a mechanism for updating or strengthening memories. Observations of an analog of reconsolidation in vitro and in sensory systems indicate that reconsolidation is unlikely to be a learning-specific phenomenon and may serve a broader function. We propose that reconsolidation arises from the activity-dependent induction of two coincident but opposing processes: the depotentiation and repotentiation of strengthened synapses. These processes suggest that reconsolidation reflects a fundamental mechanism that regulates and preserves synaptic strength.

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