Role of network dynamics in shaping spike timing reliability.

Publication Type:

Journal Article

Authors:

Bazhenov, Maxim; Rulkov, Nikolai F; Fellous, Jean-Marc; Igor Timofeev

Source:

Phys Rev E Stat Nonlin Soft Matter Phys, Volume 72, Issue 4 Pt 1, p.041903 (2005)

Keywords:

Action Potentials, Animals, Biological Clocks, Cerebral Cortex, Computer Simulation, Evoked Potentials, Humans, Models, Neurological, Nerve Net, Neurons, Synaptic Transmission

Abstract:

<p>We study the reliability of cortical neuron responses to periodically modulated synaptic stimuli. Simple map-based models of two different types of cortical neurons are constructed to replicate the intrinsic resonances of reliability found in experimental data and to explore the effects of those resonance properties on collective behavior in a cortical network model containing excitatory and inhibitory cells. We show that network interactions can enhance the frequency range of reliable responses and that the latter can be controlled by the strength of synaptic connections. The underlying dynamical mechanisms of reliability enhancement are discussed.</p>