Simon Hardy, PhD, P.eng.
Associate professor, Département d'informatique et de génie logiciel & Département de biochimie, microbiologie et bio-informatique, Université Laval
Investigator, CERVO Brain Research Centre
Development of mathematical models to understand and analyze complex biological systems
Professor Simon Hardy develops mathematical and computational models based on experimental data that allow us to analyze the complex dynamics of biological systems.
In collaboration with biologists, Dr. Hardy's team is developing theoretical models of neurons integrating physiological, biochemical and electrical current measurements in neural networks.
The models developed can predict the system's response in different situations, how the normal behavior of the system can be disrupted to lead to a disorder or disease, and determine the interventions that could restore it to a state of health.
In my group, we build realistic models of biological systems and develop analysis computational methods to study their control mechanisms.
Our mathematical and computational models are built from experimental data and allow for the exploration of the complex dynamics of biological systems. We use concepts from control theory to explain the mechanisms of cell regulation, signal transduction in particular. This helps us understand the response of systems, how a system behavior can be altered to become pathological and which interventions will restore it to a normal behavior. We develop the dynamic graph methodology and use formal methods as tools to discover new knowledge in cell biology.
We work in collaboration with biologists to integrate modeling and simulation to the «wet lab» experimental process to generate new hypotheses. We also plan to develop a new generation of theoretical models of neurons that will combine electrophysiology, biochemistry and ionic fluxes.
Azeloglu E.U., Hardy S.V. et al, Interconnected Network Motifs Control Podocyte Morphology and Kidney Function, Science Signaling, 2014, Vol. 7, Issue 311, pp. ra12, DOI: 10.1126/scisignal.2004621
Assistant professor - Université Laval, 2011 - present
Postdoctoral fellow - Systems Biology Center New York, Mount Sinai School of Medicine, Iyengar Lab 2007 - 2011
Short-term postdoctoral fellow - National Center for Biological Sciences, India, Bhalla Lab 2010
PhD - Computer engineering, École Polytechnique de Montréal
MASc - Computer engineering, École Polytechnique de Montréal
BEng - Computer engineering, École Polytechnique de Montréal
2601 Chemin de la Canardière