Membrane biophysics
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Mohamed ChahineStudy of the structure and function of sodium channels in the brain and heart to identify new therapeutic targets to improve communication between cells.Mohamed Chahine is a world-renowned expert on the structure, function and biophysical properties of sodium channels, which are channels on the surface of cells that allow entry and exit of sodium ions. Sodium channels are specifically found in the brain and the heart, where they affect the function of cells. Dr. Chahine's research has led to the characterization of sodium channels involved in several disorders including... |
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Paul De KoninckDiscoveries about the molecular mechanisms that control the connections between neurons and the development of neural circuits for learning and memoryProfessor Paul De Koninck and his team study the development of connections between neurons, called synapses, and their remodeling in response to stimuli. These mechanisms of neural circuit remodeling are the basis of learning and memory. Their precise regulation is crucial as abnormal levels of neuronal activity can lead to disorders such as Alzheimer's disease or schizophrenia. Using advanced neurophotonic technologies... |
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Yves De KoninckSynaptic transmission: from chronic pain to Alzheimer's diseaseYves De Koninck's work focuses on the transmission of signals from one neuron to another, also called synaptic transmission, and the necessary balance between excitatory and inhibitory signals in the brain and spinal cord. His research has shown how a normally benign stimulus can turn into a pain signal, leading to the development of chronic pain. One person in five will experience chronic pain in their lifetime, a proportion that increases with age. This is the leading cause of disability in the country... |
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Nicolas DoyonReaching a deeper understanding of neurons and neural networks through mathematical simulation and modeling.Professor Nicolas Doyon, from the Department of Mathematics and Statistics, uses his expertise in mathematical modeling to better understand how ion transporters influence signal processing by neurons. Precise control of the amounts of certain ions, such as chloride ions, is necessary for the proper functioning of neurons. Professor Doyon's studies have led to a better understanding of the spatio-temporal control of ion transport in neurons. Defects in the... |
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Simon HardyDevelopment of mathematical models to understand and analyze complex biological systemsProfessor Simon Hardy develops mathematical and computational models based on experimental data that allow us to analyze the complex dynamics of biological systems. In collaboration with biologists, Dr. Hardy's team is developing theoretical models of neurons integrating physiological, biochemical and electrical current measurements in neural networks. The models developed can predict the system's response in different situations, how the normal behavior of the system can be... |
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Armen SaghatelyanStudying the birth of new neurons in the brain to discover new approaches for the treatment of neurodegenerative and neurodevelopmental diseases.Research in Dr. Armen Saghatelyan’s laboratory aims to better understand how new neurons are born and integrated in the adult brain. The adult brain contains stem cells that divide to generate new neurons. Dr. Saghatelyan's team is interested in the molecular and cellular mechanisms underlying stem cell division, neuronal precursor migration and the integration of new neurons in the adult brain. The olfactory bulb, which is involved in... |
