Discoveries about the molecular mechanisms that control the connections between neurons and the development of neural circuits for learning and memory
Professor Paul De Koninck and his team study the development of connections between neurons, called synapses, and their remodeling in response to stimuli. These mechanisms of neural circuit remodeling are the basis of learning and memory. Their precise regulation is crucial as abnormal levels of neuronal activity can lead to disorders such as Alzheimer's disease or schizophrenia.
Using advanced neurophotonic technologies...
Reaching a deeper understanding of neurons and neural networks through mathematical simulation and modeling.
Professor Nicolas Doyon, from the Department of Mathematics and Statistics, uses his expertise in mathematical modeling to better understand how ion transporters influence signal processing by neurons. Precise control of the amounts of certain ions, such as chloride ions, is necessary for the proper functioning of neurons. Professor Doyon's studies have led to a better understanding of the spatio-temporal control of ion transport in neurons.
Defects in the...
Development of mathematical models to understand and analyze complex biological systems
Professor Simon Hardy develops mathematical and computational models based on experimental data that allow us to analyze the complex dynamics of biological systems.
In collaboration with biologists, Dr. Hardy's team is developing theoretical models of neurons integrating physiological, biochemical and electrical current measurements in neural networks.
The models developed can predict the system's response in different situations, how the normal behavior of the system can be...
Discovery of mechanisms underlying the development of Fragile X Syndrome
Professor Edouard Khandjian studies the molecular mechanisms underlying Fragile X syndrome, which is an inherited disease that causes significant mental retardation. Fragile X Syndrome is the most common form of hereditary mental retardation, and an important cause of autism which manifests itself in learning difficulties, language disorders and hyperactive or autistic behaviors. This syndrome is caused by the absence of Fragile X Mental Retardation Protein (FMRP), resulting from mutations in the FMR1...
Research into the causes of Parkinson's disease aiming to develop new treatments
Professor Martin Lévesque studies the development and maintenance of neural circuits that produce dopamine in the brain. His research has identified molecules that are necessary for the development, survival and integration of dopaminergic neurons in the brain. These neurons play a crucial role in movement control, mood, attention and stress response.
Dr. Lévesque's research has led to important advances in the understanding of Parkinson's disease, a neurodegenerative disease characterized by...
Psychiatric genetics and child neurodevelopment program: characterizing infant risk pathways for the prevention of schizophrenia, bipolar disorder and major depression
Dr. Michel Maziade, a clinical psychiatrist and researcher, has led a research program for more than 35 years on families affected by schizophrenia, bipolar disorder or major depression. The risk of developing these disease in children born to an affected parent is 15 to 20 times higher than that of other children. His work has shown that healthy children who are born to an affected parent can, early in life, carry...
A pioneer in the study of the organization of connections and pathways of the healthy brain, and changes that lead to the development of Huntington's and Parkinson's diseases.
Professor André Parent is a world-renowned pioneer for his research that has advanced our understanding of the role of neurons in a region of the brain called the basal ganglion. He has studied the role of these nerve structures deep under the cerebral cortex in the control of psychomotor behavior, both in normal and pathological conditions (for example in Parkinson's and Huntington's diseases).