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Yves De Koninck,

Professor of psychiatry & Neuroscience at Laval University
Adjunct Professor of Pharmacology & Therapeutics at McGill University
Scientific Director, Quebec Mental Health Institute
Director of research, Quebec Integrated University Health and Social Services Centre
Director, Neurophotonics Center (
Scientific Director, Sentinel North Initiative
Fellow, Canadian Academy of Health Sciences
Fellow Royal Society of Canada
Canada Research Chair in Chronic Pain and Related Brain Disorders - Tier 1

Our research focuses on the physiological, pharmacological and anatomical bases of synaptic transmission, with a particular emphasis on cellular substrates of pathological conditions in the Central Nervous System (CNS). Our recent work focuses on three main themes:

  1. synaptic mechanisms in the sensory spinal cord and their plasticity during development and in experimental models of chronic pain;
  2. synaptic changes in the neocortex during ageing and Alzheimer’s disease;
  3. the impact of synaptic activity on the computational properties of neurons.

We use a wide array of approaches, including electrophysiological recording in vivo (micro-optrodes) and in vitro (patch clamp in slices), multiphoton and other non-linear imaging techniques, time-resolved fluorescence microscopy, in vivo optogenetics, tissue-based biochemical analysis, neural tracing and immunocytochemistry, and computational approaches.

The lab is also actively involved in the development of novel photonics technique development, including fluctuation analysis of fluorescent signals, fibreoptic-based probe development, novel microscopy techniques and neural modeling approaches.

Yves De Koninck laboratory

Samuel Ferland M.Sc. Student
Axelle Dovonou Ph.D. student
Iason Keramidis Ph.D. student
Isabel Plasencia Ph.D. student
Jimena Perez-Sanchez Ph.D. student
Jonathan Damblon Ph.D. student
Louis Thibon Ph.D. student
Melina Papalampropoulou-Tsiridou Ph.D. student
Cyril Bories Postdoctoral fellow
Feng Wang Postdoctoral fellow
Marc Bergeron Postdoctoral fellow
Martin Cottet Postdoctoral fellow

Karine Bachand Senior research assistant
César Benavente Research assistant
Louis-Etienne Lorenzo Research assistant
Modesto Peralta Research assistant
Annie Castonguay Lab manager
Jacqueline Turmel Administrative assistant
Sylvain Côté Computer and network manager
Julie Poupart Web Site

Doyon N, Vinay L, Prescott SA, De Koninck Y. Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition. Neuron. 2016 Mar 16;89(6):1157-72. PubMed PMID: 26985723.

Prescott SA, Ma Q, De Koninck Y. Normal and abnormal coding of somatosensory stimuli causing pain. Nat Neurosci. 2014 Feb;17(2):183-91. PubMed PMID: 24473266; NIHMSID: NIHMS594482; PubMed Central PMCID: PMC4079041.

Lavertu G, Côté SL, De Koninck Y. Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model. Brain. 2014 Mar;137(Pt 3):724-38. PubMed PMID: 24369380.

Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y. Gephyrin clusters are absent from small diameter primary afferent terminals despite the presence of GABA(A) receptors. J Neurosci. 2014 Jun 11;34(24):8300-17. PubMed PMID: 24920633.

Bonin RP, De Koninck Y. A spinal analog of memory reconsolidation enables reversal of hyperalgesia. Nat Neurosci. 2014 Aug;17(8):1043-5. PubMed PMID: 24997764.

Ferrini F, Trang T, Mattioli TA, Laffray S, Del'Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, De Koninck Y. Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl? homeostasis. Nat Neurosci. 2013 Feb;16(2):183-92. PubMed PMID: 23292683.

Thériault G, De Koninck Y, McCarthy N. Extended depth of field microscopy for rapid volumetric two-photon imaging. Opt Express. 2013 Apr 22;21(8):10095-104. PubMed PMID: 23609714.

Dehez H, Piché M, De Koninck Y. Resolution and contrast enhancement in laser scanning microscopy using dark beam imaging. Opt Express. 2013 Jul 1;21(13):15912-25. PubMed PMID: 23842378.

Gagnon M, Bergeron MJ, Lavertu G, Castonguay A, Tripathy S, Bonin RP, Perez-Sanchez J, Boudreau D, Wang B, Dumas L, Valade I, Bachand K, Jacob-Wagner M, Tardif C, Kianicka I, Isenring P, Attardo G, Coull JA, De Koninck Y. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov;19(11):1524-8. PubMed PMID: 24097188; NIHMSID: CAMS3993; PubMed Central PMCID: PMC4005788.

LeChasseur Y, Dufour S, Lavertu G, Bories C, Deschênes M, Vallée R, De Koninck Y. A microprobe for parallel optical and electrical recordings from single neurons in vivo. Nat Methods. 2011 Apr;8(4):319-25. PubMed PMID: 21317908.

Godin AG, Costantino S, Lorenzo LE, Swift JL, Sergeev M, Ribeiro-da-Silva A, De Koninck Y, Wiseman PW. Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7010-5. PubMed PMID: 21482753; PubMed Central PMCID: PMC3084122.

Doyon N, Prescott SA, Castonguay A, Godin AG, Kröger H, De Koninck Y. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. PLoS Comput Biol. 2011 Sep;7(9):e1002149. PubMed PMID: 21931544; PubMed Central PMCID: PMC3169517.

Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005 Dec 15;438(7070):1017-21. PubMed PMID: 16355225.

Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sík A, De Koninck P, De Koninck Y. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature. 2003 Aug 21;424(6951):938-42. PubMed PMID: 12931188.

2016 Canada Research Chair in Chronic Pain and Related Brain Disorders (Tier 1)
2015 Université de Montréal, Honorary Doctorate
2014 Barbara Turnbull Foundation, Barbara Turnbull Award
Prize awarded to a researcher having distinguished himself on the international scene in the field of spinal cord research.
2006 – 2015 Réseau québécois de recherche sur la douleur (RQRD), Scientific Director
2014 Québec Science, top 10 discoveries of the year
2013 Association francophone pour le savoir (ACFAS), Jacques-Rousseau Prize (multidiciplinarity)
2013 Canadian Academy of Health Sciences, Fellow
2013 Le Soleil, Top 10 discoveries of the year
2013 La Presse / Radio Canada, Personality of the week
2013 Association for the Study of Neurons and Diseases, Molecular Pain Award
2013 Canadians for Medical Research, Researcher of the Month (July)
2012 La Presse / Radio Canada, Personality of the week
2012 Québec Science, top 10 discoveries of the year
2010 – 2012 Canadian Association for Neurosciences, President
2011 British PainSociety, Patrick Wall Lecture
2007 - 2011 Fonds de la recherche en santé du Québec (FRSQ), FRSQ National Scholar
Career Award
2003 - 2007 Fonds de la recherche en santé du Québec (FRSQ), FRSQ Senior Scholar
Career Award
2004 Quebec Science, Top 10 discoveries of the year 2003
2001 Canadian Pain Society, Early Career Award
2000 - 2003 Fonds de la recherche en santé du Quebec (FRSQ), FRSQ Junior II Scholar
Career Award
2000 Top 50 under 40, Radio Canada & Commerce Magazine
1998 Canadian Foundation for Innovation (CFI), New Opportunities Competition
1998 Institut de recherche clinique de Montréal, Pfizer Travelling Fellow
1995 - 2000 Medical Research Council of Canada (MRC), MRC Scholar
1995 - 1999 Fonds de la recherche en santé du Québec (FRSQ), FRSQ Jr Scholar
Career Award (declined)
1993 - 1994 Medical Research Council of Canada (MRC), Postdoctoral Fellowship
UT Southwestern Medical Center, Dallas, TX, USA
1991 - 1993 Medical Research Council of Canada (MRC), Postdoctoral Fellowship
Stanford University, Stanford, CA, USA
1990 - 1991 Faculty of Medicine, Ph.D. Studentship, McGill University, Montreal, QC, Canada
1985 - 1990 Fonds de la recherche en santé du Québec (FRSQ), Ph.D. Studentship, McGill University, Montreal, QC, Canada
1985 - 1990 Fonds de l'aide et du soutien à la recherche du Quebec (FCAR), Ph.D. Studentship (declined)
1985 - 1989 Natural Sciences and Engineering Research Council (NSERC), Ph.D. Studentship (declined)

Neurophysiology, Sensory physiology, spinal cord, neurotransmission, pain, synaptic plasticity, computational neurosciences, membrane biophysics, non-linear microscopy, optogenetics, fluorescence techniques, inhibition, membrane transport, chloride homeostasis

Yves De Koninck

(418) 663-5747


2601 Chemin de la Canardière
Québec (Québec)
G1J 2G3



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Bridging the cleft at GABA synapses in the brain., Mody, I, De Koninck Yves, Otis T S., and Soltesz I , Trends Neurosci, 1994 Dec, Volume 17, Issue 12, p.517-25, (1994)

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