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Armen Saghatelyan,
Ph.D.

Professeur Titulaire
Chaire de recherche du Canada en neurogenèse postnatale 
Département de psychiatrie et de neurosciences, Université Laval


Notre laboratoire s’intéresse à la compréhension des mécanismes cellulaires et moléculaires régissant la migration, la maturation et l’intégration fonctionnelle au sein d’un réseau neuronal mature, des neurones nouvellement générés. Le bulbe olfactif (BO) représente un modèle de choix pour l’étude de ces processus, cette région étant l’une des rares du cerveau adulte au niveau de laquelle se produisent massivement de la migration et de la maturation neuronales. Les précurseurs neuronaux sont générés au niveau de la zone sous-ventriculaire (SVZ) et migrent en direction du BO au niveau duquel ils vont s’intégrer au réseau fonctionnel. A long-terme, l’objectif de nos travaux de recherche est d’identifier les programmes moléculaires et cellulaires sous-tendant le développement neuronal dans le cerveau adulte. Cela permettrait ainsi de mettre au point des thérapies de remplacement cellulaire efficaces via l’induction d’un recrutement neuronal au niveau des régions cérébrales atteintes par diverses maladies neurodégénératives ou un traumatisme cérébral.

Nous utilisons des approches multidisciplinaires incluant l’imagerie deux-photons in vivo de la maturation neuronale et de la dynamique des épines, l’imagerie de la migration neuronale sur des tranches aigues de cerveau, l’électrophysiologie, l’imagerie calcique, la culture cellulaire, l’injection stéréotaxique de vecteurs viraux, l’électroporation, l’immunohistochimie, le western blot, mais également la caractérisation comportementale du comportement olfactif.


Armen Saghatelyan lab

Marina Snapyan (assistante de recherche)
Qian Li (stagaire postdoctoral)e
Archana Gengatharan (étudiante au doctorat)
Delphine Hardy (étudiante au doctorat)
Karen Bakhshetyan (étudiant au doctorat)
Cedric Bressan (étudiant au doctorat)
Sarah Malvaut (étudiante au doctorat)
Arutyun Bagramyan (étudiant au doctorat, codirection)
Marcos Schaan Profes (étudiant au doctorat, codirection)


1. Breton-Provencher V, Bakhshetyan K, Hardy D, Bammann RR, Cavarretta F, Snapyan M, Côté D, Migliore M, Saghatelyan A (2016) Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb. Nat Commun. 7:12659. doi: 10.1038/ncomms12659

2. Bagramyan A, Galstian T, Saghatelyan A (2016) Motion-free endoscopic system for brain imaging at variable focal depth using liquid crystal lenses. J Biophotonics. doi: 10.1002/jbio.201500261.

3. Gengatharan A, Bammann RR and Saghatelyan A (2016) The role of astrocytes in the generation, migration and integration of new neurons in the adult olfactory bulb. Frontiers in Neurogenesis doi: 10.3389/fnins.2016.00149.

4. Malvaut S and Saghatelyan A (2016) The role of adult-born neurons in the constantly changing olfactory bulb network. Neural Plasticity. doi:10.1155/2016/1614329.

 5.Bakhshetyan K and Saghatelyan A (2015) Tracking neuronal migration in adult brain slices. Curr Protoc Neurosci. 71: 3.28.1-3.28.13. doi: 10.1002/0471142301.ns0328s71

6. Breton-Provencher V, Coté D, Saghatelyan A (2014) The activity of the principal cells of the olfactory bulb promotes a structural dynamic on the distal dendrites of immature adult-born granule cells via activation of NMDA receptors. J Neurosci. 34:1748-59.

7. David L, Schachner M, Saghatelyan A (2013) The extracellular matrix glycoprotein tenascin-R affects adult but not developmental neurogenesis in the olfactory bulb. J Neurosci. 33:10324-39.

8. Bozoyan L, Khlghatyan J, and Saghatelyan A (2012) Astrocytes control the development of the migration-promoting vasculature scaffold in the postnatal brain via VEGF signaling. J Neurosci. 32:1687-704.

9. Breton-Provencher V and Saghatelyan A (2012) Adult olfactory bulb neurogenesis and odor behavior. Behav Brain Res 227: 480-9.

10. Bastien-Dionne P-O, David L, Parent A and Saghatelyan A (2010) Unilateral sensory deprivation alters adult neurogenesis in the olfactory bulb. Journal of Comparative Neurology 518:1847-61.

11. Massouh M and Saghatelyan A (2010) De-routing neuronal precursors in the adult brain to sites of injury: role of the vasculature. Neuropharmacology 58:877-83.

12. Breton-Provencher V, Lemasson M, Peralta MR and Saghatelyan A (2009) Continuous supply of interneurons during adulthood is required for the normal functioning of the olfactory bulb network. J Neurosci. 29: 15245-57. Selected by the Faculty 1000 as a must read article.

13. Saghatelyan A (2009) Role of blood vessels in the neuronal migration. Semin Cell Dev Biol. 20:744-50.

14. Snapyan M, Lemasson M, Brill MS, Blais M, Massouh M, Ninkovic J, Gravel C, Berthod F, Götz M, Barker PA, Parent A and Saghatelyan A (2009) Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. J Neurosci. 29:4172-88.


 


Dr. Armen Saghatelyan is a Full Professor at Laval University and holds Canada Research Tier II in postnatal neurogenesis. He received B.Sc. and Master degrees at Yerevan State University, Armenia and performed 1.5 years pre-docotral training in Saint-Petersburg, Russia. He then did his PhD work in Hamburg, Germany, in the lab of Prof. Melitta Schachner. During his PhD he studied the role of different cell adhesion and extracellular matrix molecules in the formation and function of inhibitory synapses. He performed two post-doctoral trainings in France; first, in the lab of Pierre-Marie Lledo, Pasteur Institut working on the olfactory bulb where arrival of new interneurons and formation of new inhibitory synapses continue throughout life and second, in the lab of Alain Prochiantz, Ecole Normale Superieure, Paris working on the role transcriptional factors in the fate specification of newborn bulbar interneurons. 
He obtained Canada Research Chair and joined Laval University in November 2005.
Dr. Saghatelyan is interested in the molecular and cellular mechanisms governing adult olfactory bulb neurogenesis and their potential in treating neurodegenerative diseases. 
 


2005 - 2015 Chaire de recherche du Canada en neurogenèse postnatale


Mots-clés: 
olfaction, neurogenese postnatale, cellules souche, migration neuronale, maturation neuronale, plasticité structurelle, maladies neurodéveloppementales

Armen Saghatelyan

 
 
 

2601 Chemin de la Canardière
Québec (Québec) 
G1J 2G3
Canada


Bureau: 
F-6561-4

 
 

Publications

Tracking neuronal migration in adult brain slices., Bakhshetyan, Karen, and Saghatelyan Armen , Curr Protoc Neurosci, 2015 Apr 01, Volume 71, p.3.28.1-13, (2015)

Financement / Soutien / Partenaires

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