Institute of Reconstructive Neurobiology
Medical Faculty, University of Bonn
A major goal of our research effort is to unravel the mechanisms that underlie the generation of diversity in the dopaminergic system. Over the recent years, we have established several novel approaches to examine dopaminergic development and provided insights into the mechanisms of specification, migration and circuit formation in the dopaminergic system (Tolve et al. Cell Reports 2021; Vaswani et al. eLife 2019; Kabanova, Pabst et al. Nature Neuroscience 2015). To investigate how these developmental processes determine the connectivity and function of midbrain dopaminergic neuronal subtypes in the adult brain, we use a combination of developmental genetic approaches, genetic tracing tools, gene expression analysis, behavioral analysis and selective manipulation of neural circuits.
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