Evaluation of electroretinography (ERG) parameters as a biomarker for ADHD.

Publication Type:

Journal Article


Prog Neuropsychopharmacol Biol Psychiatry, Volume 127, p.110807 (2023)


Attention Deficit Disorder with Hyperactivity, Biomarkers, Electroretinography, Female, Humans, Male, Photic Stimulation, Retina, Transcriptional Regulator ERG, Vision, Ocular


<p><b>BACKGROUND: </b>The retina is recognized as an accessible part of the brain due to their common embryonic origin. The electroretinogram (ERG) has proven to be a valuable tool for detecting schizophrenia and bipolarity. We therefore investigated its ability to detect ADHD.</p><p><b>METHODS: </b>The cone and rod luminance response functions of the ERG were recorded in 26 ADHD subjects (17 women and 9 men) and 25 controls (16 women and 9 men).</p><p><b>RESULTS: </b>No significant differences were found between the mixed groups, but sexual dysmorphia was observed in the significant results. In males, a significant prolonged cone a-wave latency was observed in the ADHD group. In females, we observed a significant decrease in the cone a- and b-wave amplitudes and a trend for a prolonged cone b-wave latency as well as a higher scotopic mixed rod-cone a-wave in the ADHD group.</p><p><b>CONCLUSION: </b>The data obtained in this study show the potential of the ERG to detect ADHD, warranting further large-scale studies.</p>

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