Exosomes and Epigenetic Embedding of Childhood Adversity: Crosstalk Between Mitochondria to Cell Nuclei in Stress and CNS Diseases

Conférence du Centre de recherche CERVO
Date et heure: 
Ven, 2024-04-19 11:00
Une conférence de: 
Carla Nasca

Head of Lab of Epigenetics & System Neuroscience
Tenure-track Assistant Professor
Department of Psychiatry
Department of Neuroscience & Physiology
NYU School of Medicine


At NYU School of Medicine, Dr. Nasca laboratory is working on an innovative framework of epigenetic mechanisms of neuroplasticity in stress responses and main CNS diseases with a new angle on mitochondrial metabolism. Key to this framework is the pivotal mitochondrial metabolite L-acetylcarnitine (LAC), which she discovered as a novel epigenetic modulator of hippocampal plasticity and a therapeutic target for clinical phenotypes of depression associated with childhood trauma. Newest work from her laboratory showed a role of this mitochondrial mechanism of epigenetic function as a potential therapeutic target that may be subtle to early cognitive dysfunction in the path from early-life adversity (childhood trauma) to mood disorders and progression to Alzheimer’s Disease. Using neuronal exosomes and computational approaches, her lab further showed that modulating mitochondrial metabolism of LAC is predictive of changes in other important aspects of human physiology, such as brain insulin resistance. We hope this new knowledge can ultimately lead to neurosciencebased personalized strategies for main diseases, including depression and Alzheimer’s Disease.

Dr. Carla Nasca is a tenure-track professor in the Departments of Psychiatry and Neuroscience at the New York University (NYU) School of Medicine in New York, and Head of the laboratory of Epigenetics & System Neuroscience. She joined NYU after directing her own research group at Rockefeller University in New York where she previously trained in Neuroscience with pioneering neuroscientist Bruce McEwen. She also received training in Translational Neuroscience from colleagues at Stanford University. Dr. Nasca conducted her postdoctoral studies in Neuropharmacology at Sapienza University in Rome, and she received her master’s degree Summa with Laude et Mentione from the University of Palermo. Dr. Nasca received numerous federal and foundation grants, including both a R01 grant and a High Priority research grant from National Institute of Mental Health (NIMH), and the Falk Transformative Research Award. She also is a recipient of several competitive awards, including two NARSAD awards from the Brain Behavior Research Foundation and the Blavatnik Award for Innovative Research.

Centre de recherche CERVO Brain Research Centre, 2601, de la Canardière Québec (Québec) CANADA G1J 2G3

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