Neurobiology of amyotrophic lateral sclerosis and frontotemporal dementia
The laboratory of Dr. Chantelle Sephton is seeking highly motivated Ph.D. candidates to join the Integrative Neuroscience Group at the CERVO Brain Research Center at Université Laval, Quebec City, Canada. Selected students will have the choice to enroll in one of the following graduate programs at Université Laval: Neuroscience, Biochemistry, or Cellular and Molecular Biology.
The major goals of the laboratory are to determine how processing of RNA is altered in neurodegenerative disorders, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD) and to identify new therapeutic approaches to finding a cure for these diseases. Successful applicants will have the opportunity to conduct their thesis on one of the following ongoing research projects:
Project 1. Assess the function of RNA binding proteins at excitatory synapses.
Project 2. Determine how disease-associated RNA-binding proteins alter synaptic plasticity.
Project 3. Identify of therapeutic strategies to reverse RNA binding protein toxicity.
Our laboratory uses ALS and FTLD mouse and cell culture models to study the function of RNA-binding proteins and the efficacy of therapeutics on preventing neurodegeneration. We are taking a multifaceted approach in our research employing transcriptomics, proteomics, confocal and super resolution imaging. Students can look forward to a research intense environment and access to the state-of-the-art equipment.
Candidates should submit a cover letter expressing their research interests and career goals as well as a curriculum vitae, transcripts, and two reference letters directly to Dr. Chantelle Sephton at firstname.lastname@example.org.
Chantelle F. Sephton, PhD
Centre de Recherche de l'Institut Universitaire en santé Mentale de Québec
2601, chemin de la Canardière
Québec City, Canada, G1J 2G3
Tel: (418) 663-5971, ext. 4884