CIUSSS Capitale nationale logo
 

Martin Parent,
Ph.D.

Professeur agrégé
Département de psychiatrie et neurosciences
Faculté de médecine
Université Laval


Mon laboratoire s’intéresse à l’organisation anatomique et fonctionnelle des ganglions de la base, un ensemble de structures sous-corticales impliquées dans le comportement moteur et ce, chez le rongeur, le singe et l'humain. Mes projets de recherche visent à caractériser l’altération des circuits neuronaux qui survient dans la maladie de Parkinson et la chorée de Huntington et utilisant des modèles animaux de ces maladies neurodégénératives ainsi que du tissu cérébral post-mortem humain. L’éventail d’approches méthodologiques préconisées comprend des enregistrements électrophysiologiques suivis d’injections et de reconstructions neuronales tridimensionnelles, l’examen des relations synaptiques en microscopie électronique, la localisation de neurotransmetteurs ainsi que l’analyse de matériel post-mortem humain en microscopie optique et confocale.


Martin Parent lab

Le labo en 2016


Petryszyn S, Di Paolo T, Parent A, Parent M* (2016) The number of striatal cholinergic interneurons expressing calretinin is increased in parkinsonian monkeys. Neurobiology of disease.

Eid L, Parent M* (2016) Chemical anatomy of pallidal afferents in primates. Brain Structure & Function.

Gagnon D, Grégoire L, Di Paolo T, Parent M* (2016) Serotonin hyperinnervation of the striatum with high synaptic incidence in parkinsonian monkeys. Brain Structure & Function.

Eid L, Parent A, Parent M* (2016) Asynaptic feature and heterogeneous distribution of the cholinergic innervation of the primate globus pallidus. Brain Structure & Function, 221:1139-1155.

Parent M*, Parent A (2016) The primate basal ganglia connectome as revealed by single-axon tracing. In: Kathleen S. Rockland (Ed) Axons and brain architecture. Elsevier: Amsterdam, Hollande, p. 27-37.

Eid L, Parent M* (2015) Morphological evidence for dopamine interactions with pallidal neurons in primates. Frontiers in Neuroanatomy, 9:111.

Eid L, Parent M* (2015) Cholinergic neurons intrinsic to the primate external pallidum. Synapse, 69:416-419.

Descarries L, Parent M* (2015) Asynaptic and synaptic innervation by acetylcholine neurons in the central nervous system. In: John E. Johnson Jr (Ed) The Synapse: Structure and Function. Neuroscience-Net.

Gagnon D, Parent M* (2014) Distribution of VGLUT3 in highly collateralized axons from the rat dorsal raphe nucleus as revealed by single-neuron reconstructions, PLoS ONE, 9:e87709.

Petryszyn S, Beaulieu JM, Parent A, Parent M* (2014) Distribution and morphological characteristics of striatal interneurons expressing calretinin in mice: A comparison with human and nonhuman primates. J Chemical Neuroanat, 59:51-61.

Eid L, Champigny MF, Parent A, Parent M* (2013) Quantitative and ultrastructural study of the serotonin innervation of the globus pallidus in squirrel monkeys. Eur J Neurosci, 37:1659-1668.

Parent M*, Bédard C, Pourcher E (2013) Dopaminergic innervation of the human subventricular zone: a comparison between Huntington's chorea and Parkinson's disease. Am J Neurodegener Dis. 2:221-227.

Bédard C, Wallman M-J, Pourcher E, Gould PV, Parent A, Parent M* (2011) Serotonin and dopamine striatal innervation in Parkinson’s disease and Huntington’s Chorea. Parkinsonism & Related Disorders, 17:593-598.

Parent M*, Wallman M-J, Gagnon D, Parent A (2011) Serotonin innervation of basal ganglia in monkeys and humans. J Chem Neuroanat, 41:256-265.

Wallman M-J, Gagnon D, Parent M* (2011) Serotonin innervation of human basal ganglia. Eur J Neurosci, 33:1519-1532.

Bédard C, Wallman M-J, Pourcher E, Parent A, Parent M* (2010) Intense dopamine innervation of the subventricular zone in Huntington’s disease. NeuroReport, 21:1074-1079.


Mots-clés: 
Ganglions de la base; Maladie de Parkinson; Chorée de Huntington; Neuroplasticité adaptative, Bases cellulaires et moléculaires de la communication neuronale, Neuromorphologie, Primates.

Martin Parent

 
 
(418) 663-5747 x6736

 
 

2601 Chemin de la Canardière
Québec (Québec)
G1J 2G3
Canada


Bureau: 
F-6530-1

 
 

Publications

Financement / Soutien / Partenaires

logo FRQ-S logo ctrn logo fci logo cihr irsc logo nserc logo MESI