Nav 1.5 mutations linked to dilated cardiomyopathy phenotypes: Is the gating pore current the missing link?

Publication Type:

Journal Article


Channels (Austin), Volume 8, Issue 1, p.90-4 (2014)


Cardiomyopathy, Dilated, Humans, Ion Channel Gating, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Phenotype


<p>Nav 1.5 dysfunctions are commonly linked to rhythms disturbances that include type 3 long QT syndrome (LQT3), Brugada syndrome (BrS), sick sinus syndrome (SSS) and conduction defects. Recently, this channel protein has been also linked to structural heart diseases such as dilated cardiomyopathy (DCM).</p>

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