Neuromodulation of decision-making in the addictive brain.

Publication Type:

Journal Article


Subst Use Misuse, Volume 45, Issue 11, p.1766-86 (2010)


Behavior, Addictive, Brain, Decision Making, Humans, Models, Biological, Neurotransmitter Agents, Transcranial Magnetic Stimulation


<p>Noninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects. The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors. We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions. We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders.</p>

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