Performance on spatial working memory tasks after dorsal or ventral hippocampal lesions and adjacent damage to the subiculum.

Publication Type:

Journal Article

Authors:

Potvin, Olivier; Allen, Kevin; Thibaudeau, Geneviève; Doré, François Y; Sonia Goulet

Source:

Behav Neurosci, Volume 120, Issue 2, p.413-22 (2006)

Keywords:

Analysis of Variance, Animals, Behavior, Animal, Brain Injuries, Excitatory Amino Acid Agonists, Hippocampus, Linear Models, Male, Maze Learning, Memory, Short-Term, N-Methylaspartate, Rats, Rats, Long-Evans, Space Perception

Abstract:

<p>Rats with excitotoxic lesions of the dorsal or ventral hippocampus and control rats were trained on 2 spatial working memory tasks: the standard version of the radial maze with 8 baited arms and the non-matching-to-place procedure in the T maze. Dorsal lesions produced deficits in both tasks, whereas ventral lesions did not affect learning in either of them. A volumetric analysis of subicular damage showed that dorsal hippocampal lesions caused a deficit in the non-matching-to-place only when accompanied by damage to the dorsal subiculum; on the other hand, lesions to the dorsal hippocampus impaired performance in the radial-arm maze regardless of the extent of subicular damage.</p>