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Posttraumatic epilepsy: the roles of synaptic plasticity.

Publication Type:

Journal Article

Source:

Neuroscientist, Volume 16, Issue 1, p.19-27 (2010)

Keywords:

Animals, Brain Injuries, Cerebral Cortex, Epilepsy, Humans, Neuronal Plasticity, Synapses

Abstract:

Acute cerebral cortical trauma often leads to paroxysmal activities that terminate in a few hours, but several months later, patients can develop epilepsy. The process occurring between the initial acute triggered seizures and the onset of spontaneous unprovoked seizures is termed epileptogenesis. Here the authors summarize recent morphological, electrophysiological, and computational studies demonstrating that partial cortical isolation increases the number and duration of silent states in the cortical network, boosting neuronal connectivity and network excitability. These changes develop progressively, and after several weeks their synergetic action leads to epilepsy.

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