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Transcranial direct current stimulation: a computer-based human model study.

Publication Type:

Journal Article

Source:

Neuroimage, Volume 35, Issue 3, p.1113-24 (2007)

Keywords:

Brain, Computer Simulation, Electromagnetic Fields, Finite Element Analysis, Head, Humans, Models, Neurological, Radiation Dosage, Radiometry, Scattering, Radiation, Transcranial Magnetic Stimulation

Abstract:

<p><b>OBJECTIVES: </b>Interest in transcranial direct current stimulation (tDCS) in clinical practice has been growing, however, the knowledge about its efficacy and mechanisms of action remains limited. This paper presents a realistic magnetic resonance imaging (MRI)-derived finite element model of currents applied to the human brain during tDCS.</p><p><b>EXPERIMENTAL DESIGN: </b>Current density distributions were analyzed in a healthy human head model with varied electrode montages. For each configuration, we calculated the cortical current density distributions. Analogous studies were completed for three pathological models of cortical infarcts.</p><p><b>PRINCIPAL OBSERVATIONS: </b>The current density magnitude maxima injected in the cortex by 1 mA tDCS ranged from 0.77 to 2.00 mA/cm(2). The pathological models revealed that cortical strokes, relative to the non-pathological solutions, can elevate current density maxima and alter their location.</p><p><b>CONCLUSIONS: </b>These results may guide optimized tDCS for application in normal subjects and patients with focal brain lesions.</p>

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