Transient hypolocomotion in rats repeatedly exposed to phencyclidine: an appraisal of motor function and motivation.

Publication Type:

Journal Article


Prog Neuropsychopharmacol Biol Psychiatry, Volume 31, Issue 1, p.142-50 (2007)


Acoustic Stimulation, Animals, Depression, Chemical, Excitatory Amino Acid Antagonists, Exploratory Behavior, Hallucinogens, Locomotion, Male, Motivation, Motor Activity, Phencyclidine, Psychomotor Performance, Rats, Rats, Long-Evans


<p>Spontaneous locomotion in rats is reduced about 20 h following phencyclidine (PCP) exposure. Our primary purpose was to test if locomotor irregularities would outlast drug withdrawal and be modulated by a periodic auditory stimulation during or after repeated injections. To circumscribe plausible interpretations, motor coordination and motivation were assessed as well. 10 mg/kg of PCP decreased spontaneous locomotion during the injection period whether or not a sound was presented. Those effects did not persist after a 7-day washout. Motor coordination and motivation to perform a variety of goal-driven conducts in the presence or absence of reinforcement were all unaffected by PCP treatment. The generalized hypolocomotor effects induced by PCP likely resulted from an inability to self-generate behaviors. These deficiencies were apparent in contexts where response production was not clearly specified nor supported, regardless of reward contingency.</p>

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