Publication Type:
Journal ArticleSource:
J Biomed Opt, Volume 13, Issue 1, p.010501 (2008)Keywords:
Endoscopes, Equipment Design, Equipment Failure Analysis, Microscopy, Confocal, Microscopy, Fluorescence, Multiphoton, Miniaturization, Reproducibility of Results, Sensitivity and SpecificityAbstract:
<p>The ability to conduct high-resolution fluorescence imaging in internal organs of small animal models in situ and over time can make a significant impact in biomedical research. Toward this goal, we developed a real-time confocal and multiphoton endoscopic imaging system. Using 1-mm-diameter endoscopes based on gradient index lenses, we demonstrate video-rate multicolor multimodal imaging with cellular resolution in live mice.</p>