Zebrafish CRISPR models of ALS

Conférence du Centre de recherche CERVO
Date et heure: 
Ven, 2021-02-05 11:00
Une conférence de: 
Gary A.B. Armstrong

Assistant Professor - Department of Neurology and Neurosurgery 
Montreal Neurological Institute   
Faculty of Medicine  
McGill University


Conférence Zoom
ID de réunion : 974 5045 2363
Code secret : 203940

Research interests
Gary Armstrong is Assistant Professor in the Department of Neurology and Neurosurgery at the Montreal Neurological Institute and a Killam Scholar. His research focuses on furthering our understanding of synaptic defects arising both at peripheral neuromuscular junctions and central spinal cord synapses in the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). To investigate these defects his research team uses zebrafish, an animal model uniquely suited for investigations (using electrophysiological, optogenetic, and imaging approaches) pertaining to synaptic function at all levels of the motor system. In addition, this animal model lends easily to genomic manipulations where analogous disease-associated mutations can be edited into zebrafish orthologs of human genes involved with ALS (e.g. TARDBP, FUS, and CHCHD10) using the clustered regularly interspaced short palindromic repeats (CRISPRs) mutagenic system. The development and characterization of these models will be discussed in his presentation.

Conférence Zoom
Conférence Zoom

Financement / Soutien / Partenaires

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