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Centre de recherche CERVO
Contact et liens
2301 Avenue d’Estimauville Québec (Québec) G1E 0N5 Canada
Charles-Yoland Desfossés
M. D.
Axe de recherche:
Neurosciences cliniques et cognitives
Les projets de recherche de Dr Desfossés visent à explorer les mécanismes d’action de différentes options de traitement pour la dépression. Plus particulièrement, il s’intéresse aux mécanismes d’action des propriétés antidépressives de la kétamine. Il s’intéresse également aux effets de l’électroconvulsivothérapie sur les marqueurs inflammatoires et leur relation avec la réponse clinique des symptômes dépressifs.
Publications
Charles-Yoland Desfossés; Rossana Peredo; Andréane Chabot; Jean-Philippe Carmel; Pierre-Marc Tremblay; Chantal Mérette; Geneviève Picher; Isabelle Lachance; Simon Patry; Morgane Lemasson
The Pattern of Change in Depressive Symptoms and Inflammatory Markers After Electroconvulsive Therapy: A Systematic Review Article de journal
Dans: J ECT, vol. 37, no 4, p. 291–297, 2021, ISSN: 1533-4112.
@article{pmid34294652,
title = {The Pattern of Change in Depressive Symptoms and Inflammatory Markers After Electroconvulsive Therapy: A Systematic Review},
author = {Charles-Yoland Desfossés and Rossana Peredo and Andréane Chabot and Jean-Philippe Carmel and Pierre-Marc Tremblay and Chantal Mérette and Geneviève Picher and Isabelle Lachance and Simon Patry and Morgane Lemasson},
doi = {10.1097/YCT.0000000000000782},
issn = {1533-4112},
year = {2021},
date = {2021-12-01},
journal = {J ECT},
volume = {37},
number = {4},
pages = {291--297},
abstract = {Depression is a major mental health disorder, and its pathophysiology is still largely unknown, as is the action mechanism of electroconvulsive therapy (ECT). Some evidence suggests that inflammation might play a role in depression, and several studies have attempted to demonstrate a link between ECT and cytokines. This systematic review used a qualitative analysis to assess the effect of ECT on inflammatory markers as it relates to the clinical response of depressive symptoms in major depressive disorders. The bibliographic search engines CINAHL, Embase, PsychInfo, and PubMed were used to identify articles published up to July 2020. Search terms related to depression, ECT, and inflammation were used. Descriptive statistical analyses were performed to relate changes in inflammatory markers to clinical response to ECT. Twenty-five studies were included in the analysis. No systematic increases or decreases were found in a given inflammatory marker over the ECT; however, we observed that tumor necrosis factor α and interleukin-6 (IL-6) were more often found to be decreased after ECT, whereas IL-8 and IL-10 were more often found to be increased after treatment. No trend in correlation was found between the degree of clinical improvement of depressive symptoms and the variation of any inflammatory markers, despite positive clinical response to ECT. Great heterogeneity with regard to methodology used and lack of power of the studies included in this review could explain the lack of systematic change and correlation found in this study. Future research conducted on this subject should take into account these methodological limitations to allow subsequent meta-analysis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}