@article{pmid41863358,

title = {Gaming Disorder in First Episode Psychosis: Prevalence and Impact on Symptomatology and Functioning in a Prospective Cohort Study},

author = {Maxime Huot-Lavoie and Olivier Corbeil and Laurent Béchard and Valérie Jomphe and Sophie L'Heureux and Amal Abdel-Baki and Anne-Marie Essiambre and Chantale Thériault and Ingrid Salvini and Olivier Roy and Sébastien Brodeur and Paulina Montserrat Rodriguez Cervantes and William James Desrosiers and Isabelle Giroux and Magali Dufour and Yasser Khazaal and Marie-France Demers and Marc-André Roy},

doi = {10.1093/schbul/sbaf232},

issn = {1745-1701},

year  = {2026},

date = {2026-03-01},

journal = {Schizophr Bull},

volume = {52},

number = {2},

abstract = {BACKGROUND AND HYPOTHESIS: First-episode psychosis (FEP) often coincides with comorbidities that hinder recovery. Gaming disorder (GD) has emerged as a potential concern; however, data on its prevalence and clinical impact in FEP populations remain limited. We hypothesized that GD would be more prevalent among individuals with FEP than in the general population and associated with more severe psychotic symptoms and poorer functional outcomes.nnSTUDY DESIGN: In this prospective cohort study, 284 consecutive patients aged 18-35 years admitted to an Early Intervention Service in Quebec, Canada, were assessed for GD using International Classification of Diseases-11 criteria, with up to 24 months follow-up. Psychotic symptoms and functioning were measured at baseline and at 6-month intervals using the Positive and Negative Syndrome Scale-6 items (PANSS-6) and the Social and Occupational Functioning Assessment Scale (SOFAS).nnSTUDY RESULTS: Gaming disorder was present in 7.04% (95% CI: [4.35%, 10.67%]) of the sample, exceeding the 3.3% general population estimates. Among the 105 patients who reported gaming at least monthly, those with GD (n = 20) more often played Massively Multiplayer Online Role-Playing Games, while non-GD gamers (n = 85) preferred action-adventure games. GD was associated with significantly higher PANSS-6 scores (P = .04), driven by elevated negative symptoms (P = .04). SOFAS scores were consistently lower among individuals with GD, with effect sizes increasing over time.nnCONCLUSIONS: Gaming disorder is a prevalent and clinically meaningful comorbidity in FEP, linked to greater negative symptom burden and functional impairment. These findings support the need for systematic GD screening in early psychosis services and highlight the importance of developing tailored interventions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41362155,

title = {Integrating gaming disorder into early intervention in first-episode psychosis - current knowledge and future directions},

author = {Maxime Huot-Lavoie and Olivier Cobeil and Olivier Roy and Sophie L'Heureux and Magali Dufour and Josiane Lavallée and Laurent Béchard and Sébastien Brodeur and Marie-France Demers and Marc-André Roy and Yasser Khazaal},

doi = {10.1017/ipm.2025.10150},

issn = {2051-6967},

year  = {2025},

date = {2025-12-01},

journal = {Ir J Psychol Med},

pages = {1--10},

abstract = {Gaming disorder (GD) is increasingly recognized as a clinically significant condition, yet its implications in first-episode psychosis (FEP) remain largely unexplored. This perspective article focuses on the intersection of GD and FEP, highlighting key diagnostic and treatment challenges, including symptom overlap that complicates differential diagnosis, the absence of validated screening tools, and difficulties in sustained patient engagement. Drawing insights from substance use disorder management in FEP, we propose a preliminary clinical framework for integrating GD assessment and intervention into early intervention in psychosis programs. This approach prioritizes comprehensive evaluation, patient-centered care, and a harm-reduction model that supports digital well-being. Addressing GD inFEP populations is crucial for optimizing functional recovery and promoting a holistic, recovery-oriented approach to psychiatric care. Further research is needed to refine screening tools and validate tailored interventions in this population.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40403141,

title = {Lived experience of gaming disorder among people with psychotic disorders: implications for tailored interventions and clinical management},

author = {Maxime Huot-Lavoie and Laurent Béchard and Olivier Corbeil and Olivier Roy and Sophie L'Heureux and Ingrid Salvini and Catherine Lehoux and Anne-Marie Essiambre and Chantale Thériault and Sébastien Brodeur and Marie-France Demers and Yasser Khazaal and Marc-André Roy},

doi = {10.1097/YCO.0000000000001013},

issn = {1473-6578},

year  = {2025},

date = {2025-07-01},

journal = {Curr Opin Psychiatry},

volume = {38},

number = {4},

pages = {295--301},

abstract = {PURPOSE OF REVIEW: Despite growing recognition of the impact of Gaming Disorder in individuals with psychotic disorders, little is known about the clinical and personal implications of this dual diagnosis. Preliminary data suggest that Gaming Disorder may be associated with increased psychotic symptoms and reduced occupational and social functioning. However, insight from lived experience remain largely absent, despite their importance.nnRECENT FINDINGS: This review synthesizes recent literature on the comorbidity between Gaming Disorder and psychotic disorders, highlighting the scarcity of research in this emerging field. It also presents preliminary findings from an ongoing qualitative study focussing on the lived experiences of individuals receiving early psychosis intervention. These data focus on participants' motivations for gaming and their perceptions of both positive and negative effects gaming has on their life.nnSUMMARY: This review underscores the significant lack of data on the dual diagnosis of Gaming Disorder and psychosis. Early qualitative insights reveal diverse gaming motivations, including symptom regulation, anxiety management, cognitive stimulation, and social connection. These first-person accounts emphasize the functional role of gaming and the need for recovery-oriented care. Integrating lived experience into research and clinical practice can improve relevance, support nuanced interventions, and advance our understanding of behavioral addictions in early psychosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39383933,

title = {Involvement of muscarinic acetylcholine receptor-mediated cholinergic neurotransmission in TMS-EEG responses},

author = {Yufei Song and Pedro C Gordon and Olivier Roy and Johanna Metsomaa and Paolo Belardinelli and Maryam Rostami and Ulf Ziemann},

doi = {10.1016/j.pnpbp.2024.111167},

issn = {1878-4216},

year  = {2025},

date = {2025-01-01},

journal = {Prog Neuropsychopharmacol Biol Psychiatry},

volume = {136},

pages = {111167},

abstract = {The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a valuable tool for investigating brain functions in health and disease. However, the detailed neural mechanisms underlying TMS-EEG responses, including TMS-evoked EEG potentials (TEPs) and TMS-induced EEG oscillations (TIOs), remain largely unknown. Combining TMS-EEG with pharmacological interventions provides a unique opportunity to elucidate the roles of specific receptor-mediated neurotransmissions in these responses. Here, we investigated the involvement of muscarinic acetylcholine receptor (mAChR)-mediated cholinergic neurotransmission in TMS-EEG responses by evaluating the effects of mAChR antagonists on TEPs and TIOs in twenty-four healthy participants using a randomized, placebo-controlled crossover design. TEPs and TIOs were measured before and after administering a single oral dose of scopolamine (a non-selective mAChR antagonist), biperiden (an M1 mAChR antagonist), or placebo, with TMS targeting the left medial prefrontal cortex (mPFC), angular gyrus (AG), and supplementary motor area (SMA). The results indicated that mAChR-mediated cholinergic neurotransmission played a role in TEPs, but not TIOs, in a target-specific manner. Specifically, scopolamine significantly increased the amplitude of a local TEP component between approximately 40 and 63 ms post-stimulus when TMS was applied to the SMA, but not the mPFC or AG. Biperiden produced a similar but less pronounced effect. Importantly, the effects of these mAChR antagonists on TEPs were independent of those on sensory-evoked EEG potentials caused by TMS-associated sensory stimulation. These findings expand our understanding of TMS-EEG physiology, providing insights for its application in physiological and clinical research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid34791677,

title = {Whole-brain morphometry in Canadian soldiers with posttraumatic stress disorder},

author = {Olivier Roy and Jean Levasseur-Moreau and Emmanuelle Renauld and Luc J Hébert and Jean Leblond and Mathieu Bilodeau and Shirley Fecteau},

doi = {10.1111/nyas.14707},

issn = {1749-6632},

year  = {2022},

date = {2022-03-01},

journal = {Ann N Y Acad Sci},

volume = {1509},

number = {1},

pages = {37--49},

abstract = {Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers from the Canadian Armed Forces with adulthood war-related PTSD using structural magnetic resonance imaging. We assessed time since trauma, as well as PTSD, depressive, and anxiety symptoms with the Modified PTSD Symptoms Scale, Beck Depression Inventory, and Beck Anxiety Inventory, respectively. Whole-brain morphometry was extracted with FreeSurfer and compared with a validated normative database of more than 2700 healthy individuals. Volume and thickness from several regions differed from the norms. Frontal regions were smaller and thinner, particularly the superior and rostral middle frontal gyri. Furthermore, smaller left rostral middle frontal gyrus, left pericalcarine cortex, and right fusiform gyrus were associated with more recent trauma. All subcortical structures were bigger, except the hippocampus. These findings suggest a particular brain morphometric signature of PTSD in soldiers. Smaller and thinner frontal and larger subcortical regions support impaired top-down and/or downregulation of emotional response in PTSD. Finally, the correlation of smaller frontal, temporal, and occipital regions with more recent trauma might inform future therapeutic approaches.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}